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AB106628

Anti-ZBTB9 antibody

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(1 Publication)

Rabbit Polyclonal ZBTB9 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Zinc finger and BTB domain-containing protein 9.

View Alternative Names

Zinc finger and BTB domain-containing protein 9, ZBTB9

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZBTB9 antibody (AB106628)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZBTB9 antibody (AB106628)

Immunohistochemistry of ZBTB9 in mouse heart tissue with ab106628 at 2.5 μg/mL.

Immunocytochemistry/ Immunofluorescence - Anti-ZBTB9 antibody (AB106628)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ZBTB9 antibody (AB106628)

Immunofluorescence of ZBTB9 in mouse heart tissue with ab106628 at 20 ug/mL.

Western blot - Anti-ZBTB9 antibody (AB106628)
  • WB

Unknown

Western blot - Anti-ZBTB9 antibody (AB106628)

All lanes:

Western blot - Anti-ZBTB9 antibody (ab106628) at 1 µg/mL

Lane 1:

Mouse heart tissue lysate at 15 µg

Lane 2:

Mouse heart tissue lysate at 15 µg with blocking peptide

Predicted band size: 50 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human Zinc finger and BTB domain-containing protein 9. The exact immunogen used to generate this antibody is proprietary information.

Q96C00

Specificity

ab106628 is predicted to not cross-react with other ZBTB family members

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Cell Lines & Lysates

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Advanced Validation

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Primary Antibodies

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Anti-ACE2 antibody [EPR4435(2)]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACE2 antibody [EPR4435(2)] (AB108252)

  • 4
  • 10
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab106628 is purified by affinity chromatography via a peptide column.
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZBTB9 also known as Zinc Finger and BTB Domain-Containing Protein 9 is a transcription factor involved in gene expression regulation. It has an approximate mass of 56 kDa. The protein contains a conserved C2H2-type zinc finger domain which allows it to bind specific DNA sequences and modulate transcription. ZBTB9 is mainly expressed in the human brain and various tissues indicating a broad role in physiological processes. This protein's activity is essential for the regulation of genes involved in numerous cellular functions.
Biological function summary

Expertise in transcription regulation reveals ZBTB9 as a significant player. It often functions individually but can associate with other proteins to form complexes that may influence its role in transcription repression or activation. ZBTB9 interacts with different transcriptional co-repressors and co-activators to control the expression of target genes involved in cell cycle regulation apoptosis and differentiation. This precise gene regulation allows the cell to respond to various developmental and external stimuli maintaining cellular homeostasis.

Pathways

Current studies connect ZBTB9 to important transcriptional pathways like the Wnt signaling path and the cell cycle control path. In the Wnt pathway ZBTB9 interacts with proteins such as β-catenin to modulate gene expression important for cell proliferation and differentiation. In the cell cycle path it may interact with key regulators like cyclins and CDKs to influence cell division ensuring proper cell cycle progression and arrest when necessary. These interactions place ZBTB9 as a pivotal mediator in pathways affecting cellular growth and development.

Understanding the connection of ZBTB9 to pathological conditions can provide insights into its clinical significance. ZBTB9 has shown relevance in neurodegenerative diseases particularly Alzheimer's disease due to its expression in the brain and association with neural cell functions. It also appears in studies related to cancer biology with connections to proteins such as p53 indicating a role in tumorigenesis processes like cell cycle dysregulation and apoptosis resistance. These associations suggest that ZBTB9 could be a potential target for therapeutic strategies in diseases where its pathways and interactions are disrupted.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in transcriptional regulation.
See full target information Zinc finger and BTB domain-containing protein 9
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Genes & development 31:260-274 PubMed28242625

2017

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.

Applications

Unspecified application

Species

Unspecified reactive species

Justin W C Leung,Nodar Makharashvili,Poonam Agarwal,Li-Ya Chiu,Renaud Pourpre,Michael B Cammarata,Joe R Cannon,Alana Sherker,Daniel Durocher,Jennifer S Brodbelt,Tanya T Paull,Kyle M Miller
View all publications
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Product promise

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