AB241595

Anti-ZC3H11A antibody

Name: Anti-ZC3H11A antibody (ab241595) | Abcam
Brand: Abcam Limited
SKU: AB241595
Price: 510 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal ZC3H11A antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZC3H11A aa 750 to C-terminus.

View Alternative Names

KIAA0663, ZC3HDC11A, ZC3H11A, Zinc finger CCCH domain-containing protein 11A

2 Images

Supplier Data

Immunoprecipitation - Anti-ZC3H11A antibody (AB241595)

ZC3H11A was immunoprecipitated from HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate (1 mg for IP, 20% of IP loaded) using ab241595 at 3 μg/mg lysate. Western blot was performed on the immunoprecipitate using ab241595 at 1 μg/ml.

Lane 1 : ab241595 IP in HeLa whole cell lysate.
Lane 2 : Control IgG in HeLa whole cell lysate.

Detection : Chemiluminescence with an exposure time of 10 seconds.

All lanes:

Immunoprecipitation - Anti-ZC3H11A antibody (ab241595)

Predicted band size: 89 kDa

false

Supplier Data

Western blot - Anti-ZC3H11A antibody (AB241595)

All lanes:

Western blot - Anti-ZC3H11A antibody (ab241595) at 0.04 µg/mL

Lane 1:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg

Lane 2:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 15 µg

Lane 3:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 5 µg

Predicted band size: 89 kDa

true

Exposure time: 3min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IP

applications

Immunogen

Synthetic Peptide within Human ZC3H11A aa 750 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O75152

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-5 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chicken": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

ab241595 was affinity purified using an epitope specific to ZC3H11A immobilized on solid support.

Storage buffer

pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZC3H11A also known as zinc finger CCCH-type containing 11A is a protein encoded by the ZC3H11A gene. With a molecular mass of approximately 97 kDa this protein can be found expressed in various tissues with elevated levels in the brain heart and liver. Mechanically ZC3H11A functions as an RNA-binding protein participating in interactions with mRNA molecules. It contains a zinc finger domain that facilitates its interactions with nucleic acids influencing RNA stability and processing.

Biological function summary

This protein has a role in regulating mRNA stability and nuclear export. It often acts as a part of the larger mRNA export complex which includes other proteins that facilitate the transport of mRNA from the nucleus to the cytoplasm. By participating in the control of gene expression at the post-transcriptional level ZC3H11A contributes to cellular homeostasis and response to stress stimuli.

Pathways

This protein functions in the mRNA processing and transport pathways. It interacts with TREX (Transcription/Export) complex components such as Aly/REF export factor (ALYREF) to ensure proper mRNA export from the nucleus. ZC3H11A also integrates into the post-transcriptional gene regulation pathway aligning with proteins like THOC1 and THOC5 ensuring the precise control of gene expression by managing RNA fate within the cell.

Mutations or dysregulation of the ZC3H11A protein have implications in neurodegenerative diseases particularly those affecting mRNA processing and transport. For instance aberrant function of this protein has been studied in the context of Alzheimer's disease where RNA transport misregulation plays a role. ZC3H11A's connection to the THOC complex which is important in RNA metabolism links it to oncology where altered mRNA export mechanisms can contribute to cancer progression.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

RNA-binding protein that interacts with purine-rich sequences and is involved in nuclear mRNA export; probably mediated by association with the TREX complex.. (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA Export.

See full target information ZC3H11A

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular psychiatry 30:5777-5789 PubMed40913114

2025

Hyperactivity of subicular parvalbumin interneurons drives early amyloid pathology and cognitive deficits in Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Yan-Bing Chen,Bo Jiang,Kai Zhuang,He Wang,Hui-Min Peng,Bo-Wen Zhong,Wen-Ting Xie,Kai-Wei Chen,Ting-Ting Zou,Ya Wang,Hui-Li Yang,Qingwei Yang,Jiechao Zhou,Li Zhong,Li-Hua Zhang,Jie Zhang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ZC3H11A antibody

Immunoprecipitation - Anti-ZC3H11A antibody (AB241595)

Western blot - Anti-ZC3H11A antibody (AB241595)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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