AB99930

Anti-ZC3H11A antibody

Name: Anti-ZC3H11A antibody (ab99930) | Abcam
Brand: Abcam Limited
SKU: AB99930
Price: 510 USD
Availability: InStock

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(4 Publications)

Rabbit Polyclonal ZC3H11A antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZC3H11A aa 300-600.

View Alternative Names

KIAA0663, ZC3HDC11A, ZC3H11A, Zinc finger CCCH domain-containing protein 11A

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZC3H11A antibody (AB99930)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZC3H11A antibody (AB99930)

ab99930, at 1/100 dilution, staining ZC3H11A in formalin-fixed paraffin-embedded Human breast carcinoma tissue.

Unknown

Western blot - Anti-ZC3H11A antibody (AB99930)

All lanes:

Western blot - Anti-ZC3H11A antibody (ab99930) at 1/500 dilution

Lane 1:

Human fetal brain lysate

Lane 2:

Human fetal lung lysate

Lane 3:

Human fetal kidney lysate

Predicted band size: 89 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ZC3H11A aa 300-600. The exact immunogen used to generate this antibody is proprietary information.

O75152

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Preservative: 0.02% Sodium azide

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZC3H11A also known as zinc finger CCCH-type containing 11A is a protein encoded by the ZC3H11A gene. With a molecular mass of approximately 97 kDa this protein can be found expressed in various tissues with elevated levels in the brain heart and liver. Mechanically ZC3H11A functions as an RNA-binding protein participating in interactions with mRNA molecules. It contains a zinc finger domain that facilitates its interactions with nucleic acids influencing RNA stability and processing.

Biological function summary

This protein has a role in regulating mRNA stability and nuclear export. It often acts as a part of the larger mRNA export complex which includes other proteins that facilitate the transport of mRNA from the nucleus to the cytoplasm. By participating in the control of gene expression at the post-transcriptional level ZC3H11A contributes to cellular homeostasis and response to stress stimuli.

Pathways

This protein functions in the mRNA processing and transport pathways. It interacts with TREX (Transcription/Export) complex components such as Aly/REF export factor (ALYREF) to ensure proper mRNA export from the nucleus. ZC3H11A also integrates into the post-transcriptional gene regulation pathway aligning with proteins like THOC1 and THOC5 ensuring the precise control of gene expression by managing RNA fate within the cell.

Mutations or dysregulation of the ZC3H11A protein have implications in neurodegenerative diseases particularly those affecting mRNA processing and transport. For instance aberrant function of this protein has been studied in the context of Alzheimer's disease where RNA transport misregulation plays a role. ZC3H11A's connection to the THOC complex which is important in RNA metabolism links it to oncology where altered mRNA export mechanisms can contribute to cancer progression.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed : 22928037, PubMed : 37356722). Binds RNA (PubMed : 29610341, PubMed : 37356722).. (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed : 29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed : 37356722).

See full target information ZC3H11A

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

eLife 12: PubMed40864167

2025

mutations cause high myopia by triggering PI3K-AKT and NF-κB-mediated signaling pathway in humans and mice.

Applications

Unspecified application

Species

Unspecified reactive species

Chong Chen,Qian Liu,Cheng Tang,Yu Rong,Xinyi Zhao,Dandan Li,Fan Lu,Jia Qu,Xinting Liu

Nature communications 16:231 PubMed39747894

2025

L3MBTL3 and STAT3 collaboratively upregulate SNAIL expression to promote metastasis in female breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jianpeng Xiao,Jie Wang,Jialun Li,Jie Xiao,CuiCui Liu,Libi Tan,Yanhong Tu,Ruifang Yang,Yujie Pei,Minghua Wang,Jiemin Wong,Binhua P Zhou,Jing Li,Jing Feng

Frontiers in microbiology 14:1296725 PubMed38033582

2023

Analysis of the mRNA export protein ZC3H11A in HCMV infection and pan-cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jiawen Li,Min Song,Zhen Liu,Fulong Nan,Bin Wang,Dongmeng Qian,Ming Hu

The Journal of biological chemistry 299:104959 PubMed37356722

2023

The RNA-binding protein ZC3H11A interacts with the nuclear poly(A)-binding protein PABPN1 and alters polyadenylation of viral transcripts.

Applications

Unspecified application

Species

Unspecified reactive species

Katharina Kases,Erik Schubert,Zamaneh Hajikhezri,Mårten Larsson,Priya Devi,Mahmoud Darweesh,Leif Andersson,Göran Akusjärvi,Tanel Punga,Shady Younis

View all publications

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Product promise

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-ZC3H11A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZC3H11A antibody (AB99930)

Western blot - Anti-ZC3H11A antibody (AB99930)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

Product promise