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AB106710

Anti-ZC3H12B antibody

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(2 Publications)

Rabbit Polyclonal ZC3H12B antibody. Suitable for WB and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ZC3H12B.

View Alternative Names

CXorf32, MCPIP2, ZC3H12B, Probable ribonuclease ZC3H12B, MCP-induced protein 2, Zinc finger CCCH domain-containing protein 12B

1 Images
Western blot - Anti-ZC3H12B antibody (AB106710)
  • WB

Unknown

Western blot - Anti-ZC3H12B antibody (AB106710)

All lanes:

Western blot - Anti-ZC3H12B antibody (ab106710) at 1 µg/mL

Lane 1:

Mouse brain tissue lysate at 15 µg

Lane 2:

Mouse brain tissue lysate at 15 µg with blocking peptide

Predicted band size: 93 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ZC3H12B. The exact immunogen used to generate this antibody is proprietary information.

Q5HYM0

Specificity

ab106710 will not crossreact with other members of the ZC3H12 family.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZC3H12B also known as MCPIP2 is a ribonuclease enzyme with a known mass of approximately 94 kDa. It has a zinc finger CCCH-type domain that allows it to bind RNA. ZC3H12B is expressed in various tissues with higher levels observed in the heart placenta and skeletal muscle. This protein functions mechanically by degrading mRNA regulating the stability and turnover of specific transcripts.
Biological function summary

The protein acts as a post-transcriptional regulator impacting gene expression at the RNA level. ZC3H12B is not known to be part of a larger complex but interacts with other molecules to mediate its functions. It influences immune responses and inflammatory processes by controlling cytokine mRNA decay suggesting a role in modulating immune homeostasis.

Pathways

ZC3H12B integrates into key signaling cascades influencing inflammation and immune regulation. It functions in the interleukin-6 (IL-6) signaling pathway affecting inflammation responses. ZC3H12B also relates to the tumor necrosis factor (TNF) pathway sharing activities with proteins like ZC3H12A and Regnase-1 which similarly impact cytokine mRNA stability and turnover.

ZC3H12B holds relevance in conditions such as rheumatoid arthritis and lupus both involving dysregulated immune responses. In rheumatoid arthritis ZC3H12B influences inflammation by regulating cytokine mRNA similar to its homolog ZC3H12A. In lupus disturbances in ZC3H12B expression or function could potentially alter cytokine profiles linking it to disease pathogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May function as RNase and regulate the levels of target RNA species.
See full target information ZC3H12B
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Molecular therapy oncolytics 20:484-498 PubMed33718596

2021

M2 macrophage-derived exosomal microRNA-155-5p promotes the immune escape of colon cancer by downregulating ZC3H12B.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Shui Ma,Ting-Miao Wu,Chang-Chun Ling,Fei Yu,Jie Zhang,Ping-Sheng Cao,Li-Peng Gu,Hui-Ming Wang,Hong Xu,Liu Li,Zhi-Jun Wu,Gao-Ren Wang,Wen Li,Qin-Lu Lin,Ji-Bin Liu,Da Fu

Metabolites 10: PubMed32235559

2020

Enhancing Glycolysis Protects against Ischemia-Reperfusion Injury by Reducing ROS Production.

Applications

Unspecified application

Species

Unspecified reactive species

Claudia Beltran,Rosario Pardo,Diana Bou-Teen,Marisol Ruiz-Meana,Josep A Villena,Ignacio Ferreira-González,Ignasi Barba
View all publications
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