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AB118601

Anti-ZC3H12C antibody

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(1 Publication)

Rabbit Polyclonal ZC3H12C antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZC3H12C conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

KIAA1726, MCPIP3, ZC3H12C, Probable ribonuclease ZC3H12C, MCP-induced protein 3, Zinc finger CCCH domain-containing protein 12C

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZC3H12C antibody (AB118601)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZC3H12C antibody (AB118601)

ab118601, at 5 µg/ml, staining ZC3H12C in formalin fixed, paraffin embedded Human skin tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human ZC3H12C conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9C0D7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZC3H12C also known as MCPIP3 or Regnase-3 functions mechanically as a ribonuclease involved in mRNA degradation. It has a molecular mass of about 62 kDa. This protein is expressed in various tissues including lung and spleen with notable expression in immune-related cells. ZC3H12C contains a PIN-like domain that is critical for its ribonuclease activity playing an important role in the regulation of inflammation by controlling RNA stability.
Biological function summary

The ZC3H12C protein regulates inflammation by targeting specific mRNAs for degradation therefore modulating the immune response. It is part of the MCPIP family of ribonucleases which share structural similarities and functional roles in cellular processes. ZC3H12C affects cytokine production by degrading mRNA of pro-inflammatory cytokines therefore fine-tuning the levels of inflammatory mediators.

Pathways

The involvement of ZC3H12C in the immune system is significant through its role in the cytokine signaling pathway. It works in conjunction with other MCPIP family proteins such as ZC3H12A. The protein modulates important pathways like the NF-kB signaling pathway which is important for immune responses. ZC3H12C's interplay with various cytokines and signaling molecules positions it as an essential regulator within the immune response pathway network.

ZC3H12C influences conditions like inflammatory diseases and cancer. Abnormal regulation of this protein and its pathways can exacerbate inflammatory disorders due to unregulated cytokine production. Evidence links ZC3H12C to certain cancers where it may interact with proteins such as ZC3H12A impacting tumor progression and immune evasion. Understanding these interactions provides insights into potential therapeutic targets for managing inflammation-related conditions and certain cancers.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May function as RNase and regulate the levels of target RNA species.
See full target information ZC3H12C
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular reproduction and development 92:e70049 PubMed40838423

2025

Three-Dimensional Magnetic Bioprinting Spheroids as an In Vitro Model to Study the Oviductal Physiology.

Applications

Unspecified application

Species

Unspecified reactive species

Patricia Kubo Fontes,Ana Beatriz Florencio da Silva,Ana Beatriz Dos Reis Bartoli,Thays Antunes,Arnaldo Rodrigues Dos Santos Júnior,Marcella Pecora Milazzotto
View all publications
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Product promise

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