Anti-ZC3H12C antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ZC3H12C also known as MCPIP3 or Regnase-3 functions mechanically as a ribonuclease involved in mRNA degradation. It has a molecular mass of about 62 kDa. This protein is expressed in various tissues including lung and spleen with notable expression in immune-related cells. ZC3H12C contains a PIN-like domain that is critical for its ribonuclease activity playing an important role in the regulation of inflammation by controlling RNA stability.

Biological function summary

The ZC3H12C protein regulates inflammation by targeting specific mRNAs for degradation therefore modulating the immune response. It is part of the MCPIP family of ribonucleases which share structural similarities and functional roles in cellular processes. ZC3H12C affects cytokine production by degrading mRNA of pro-inflammatory cytokines therefore fine-tuning the levels of inflammatory mediators.

Pathways

The involvement of ZC3H12C in the immune system is significant through its role in the cytokine signaling pathway. It works in conjunction with other MCPIP family proteins such as ZC3H12A. The protein modulates important pathways like the NF-kB signaling pathway which is important for immune responses. ZC3H12C's interplay with various cytokines and signaling molecules positions it as an essential regulator within the immune response pathway network.

Associated diseases and disorders

ZC3H12C influences conditions like inflammatory diseases and cancer. Abnormal regulation of this protein and its pathways can exacerbate inflammatory disorders due to unregulated cytokine production. Evidence links ZC3H12C to certain cancers where it may interact with proteins such as ZC3H12A impacting tumor progression and immune evasion. Understanding these interactions provides insights into potential therapeutic targets for managing inflammation-related conditions and certain cancers.