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AB88756

Anti-ZCCHC2 antibody

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(2 Publications)

Mouse Polyclonal ZCCHC2 antibody. Carrier free. Suitable for WB and reacts with Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZCCHC2 aa 1-400.

View Alternative Names

C18orf49, KIAA1744, ZCCHC2, Zinc finger CCHC domain-containing protein 2

2 Images
Western blot - Anti-ZCCHC2 antibody (AB88756)
  • WB

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Western blot - Anti-ZCCHC2 antibody (AB88756)

All lanes:

Western blot - Anti-ZCCHC2 antibody (ab88756) at 1 µg/mL

All lanes:

Rat brain tissue lysate at 50 µg

Predicted band size: 126 kDa

Observed band size: 126 kDa

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Western blot - Anti-ZCCHC2 antibody (AB88756)
  • WB

Unknown

Western blot - Anti-ZCCHC2 antibody (AB88756)

All lanes:

Western blot - Anti-ZCCHC2 antibody (ab88756) at 1 µg/mL

Lane 1:

ZCCHC2 transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Predicted band size: 126 kDa

Observed band size: 40 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Rat, Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human ZCCHC2 aa 1-400. The exact immunogen used to generate this antibody is proprietary information.

Q9C0B9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The zinc finger CCHC domain-containing protein 2 also known as ZCCHC2 functions mechanically as an RNA-binding protein. It plays a role in RNA metabolic processes. ZCCHC2 is approximately 90 kDa in mass and includes several zinc finger motifs that are important for its interaction with RNA. It is expressed highly in the nucleus of cells across various tissues with notable levels in the brain and other central nervous system structures. This indicates its involvement in regulating RNA under specific physiological conditions.
Biological function summary

ZCCHC2 interacts with the cellular machinery involved in RNA splicing and processing. It is part of ribonucleoprotein complexes that facilitate these functions. This protein assists in modulating RNA stability and contributes to the precise processing required for mature RNA molecules. These activities are important for maintaining proper gene expression by ensuring that RNA transcripts are accurately produced and modified before translation occurs.

Pathways

ZCCHC2 plays a role in RNA processing and degradation pathways. It acts within the spliceosomal complex aiding in the proper removal of introns from pre-mRNA. ZCCHC2 interacts with other proteins such as components of the Human spliceosome which include splicing factors that orchestrate the splicing process. It also connects with pathways linked to RNA surveillance mechanisms where it helps in quality control of RNA transcripts.

ZCCHC2 has connections to neurological conditions and cancer. Abnormal expression levels or mutations in ZCCHC2 may relate to altered splicing activities leading to neurodevelopmental disorders. Additionally its dysregulation might contribute to the genesis of certain cancers through disrupted RNA processing. Proteins like spliceosomal components and RNA-binding proteins are usually involved in such diseases highlighting the importance of balanced ZCCHC2 function for cellular health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information ZCCHC2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Chembiochem : a European journal of chemical biology 24:e202300108 PubMed37166757

2023

Identifying E3 Ligase Substrates With Quantitative Degradation Proteomics.

Applications

Unspecified application

Species

Unspecified reactive species

Victoria N Jordan,Alban Ordureau,Heeseon An

The Journal of biological chemistry 290:5685-95 PubMed25561728

2015

Mechanism-based proteomic screening identifies targets of thioredoxin-like proteins.

Applications

Unspecified application

Species

Unspecified reactive species

Lia S Nakao,Robert A Everley,Stefano M Marino,Sze M Lo,Luiz E de Souza,Steven P Gygi,Vadim N Gladyshev
View all publications
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