Anti-ZCCHC4 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ZCCHC4 also known as zinc finger CCHC-type containing 4 is a protein that functions as a methyltransferase specifically modifying mRNA by adding a methyl group at the N6 position of adenine. It has an estimated mass of approximately 66 kDa. Expression of ZCCHC4 is observed mainly in the nucleus of cells and it is found across various human tissues indicating its widespread functional importance.

Biological function summary

The methyltransferase activity of ZCCHC4 plays an important role in post-transcriptional regulation of mRNA influencing its stability and translation efficiency. ZCCHC4 is part of a complex that also includes other proteins involved in RNA metabolism. Its function impacts gene expression by modulating the epigenetic marks on mRNA thereby altering the cellular response to different stimuli.

Pathways

ZCCHC4 contributes significantly to the epitranscriptome particularly affecting the m6A RNA methylation pathway. This modification is vital for processes like RNA splicing export and degradation. ZCCHC4 interacts with related proteins such as METTL3 and METTL14 which are core components of the m6A methyltransferase complex highlighting its integration within this regulatory network.

Associated diseases and disorders

Alterations in ZCCHC4 expression or function associate with certain cancers including liver cancer. Dysregulation of m6A modification in which ZCCHC4 is involved contributes to tumor progression and metastasis. Research has also linked ZCCHC4 to mental disorders with evidence suggesting that abnormal mRNA methylation affects neural gene expression. ZCCHC4's interactions with proteins like ALKBH5 an m6A demethylase further illustrate its involvement in the pathogenesis of these diseases.