Rabbit Polyclonal ZCCHC6 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TUT7 aa 800-850.
View Alternative Names
HS2, KIAA1711, ZCCHC6, TUT7, Terminal uridylyltransferase 7, TUTase 7, Zinc finger CCHC domain-containing protein 6
- IP
Supplier Data
Immunoprecipitation - Anti-ZCCHC6 antibody (AB226294)
ZCCHC6 was immunoprecipitated from HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate (1 mg for IP, 20% of IP loaded) with ab226294 at 6 μg per reaction. Western blot was performed from the immunoprecipitate using ab226294 at 1 μg/ml.
Lane 1 : ab226294 IP in HEK-293T whole cell lysate.
Lane 2 : Control IgG IP in HEK-293T whole cell lysate.
Detection : Chemiluminescence with exposure time of 3 minutes.
All lanes:
Immunoprecipitation - Anti-ZCCHC6 antibody (ab226294)
Predicted band size: 171 kDa
false
- WB
Supplier Data
Western blot - Anti-ZCCHC6 antibody (AB226294)
Cells prepared using NETN lysis buffer.
All lanes:
Western blot - Anti-ZCCHC6 antibody (ab226294) at 0.1 µg/mL
Lane 1:
HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg
Lane 2:
HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 50 µg
Lane 3:
Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 50 µg
Predicted band size: 171 kDa
true
Exposure time: 3min
Alternative Products
Complementary Products
Reactivity data
Properties and storage information
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Purification notes
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Shipped at conditions
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Aliquoting information
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Supplementary information
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Biological function summary
ZCCHC6 contributes to RNA metabolism influencing RNA stability translation and degradation. It participates in the post-transcriptional regulation of gene expression by adding uridines to mRNA and non-coding RNAs which can impact the decay and processing of these RNA molecules. ZCCHC6 is also part of a dynamic complex that includes components like poly(A) polymerases interacting with various cofactors to modulate RNA length and stability.
Pathways
The processes involving ZCCHC6 play significant roles in RNA processing pathways and in the regulation of gene expression. Its activity contributes to the RNA surveillance pathway which ensures the quality control of RNA transcripts. ZCCHC6 interacts with other key proteins such as ZCCHC11 which shares similar protein domains and functions in RNA uridylation reinforcing its cooperation in these pathways.
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Target data
Publications (1)
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Oncology letters 23:35 PubMed34966451
2021
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
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