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AB104503

Anti-ZCCHC7 antibody

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(1 Publication)

Rabbit Polyclonal ZCCHC7 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZCCHC7 aa 50 to C-terminus.

View Alternative Names

HSPC086, ZCCHC7, Zinc finger CCHC domain-containing protein 7, TRAMP-like complex RNA-binding factor ZCCHC7

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZCCHC7 antibody (AB104503)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZCCHC7 antibody (AB104503)

ab104503, at 1/100 dilution, staining ZCCHC7 in formalin-fixed, paraffin-embedded Human small intestine by Immunohistochemistry.

Western blot - Anti-ZCCHC7 antibody (AB104503)
  • WB

Supplier Data

Western blot - Anti-ZCCHC7 antibody (AB104503)

All lanes:

Western blot - Anti-ZCCHC7 antibody (ab104503) at 1/1000 dilution

All lanes:

Human brain tissue lysate

Predicted band size: 63 kDa

Observed band size: 63 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ZCCHC7 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8N3Z6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute in 200 µL of water
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZCCHC7 also known as Zinc Finger CCHC-Type Containing 7 is a protein that binds RNA and plays an essential role in RNA processing. This protein has a mass of approximately 96 kDa and is expressed in various human tissues including the brain and immune cells. It participates in the nuclear exosome machinery interacting with RNA substrates to influence their maturation and stability. ZCCHC7 through these interactions is important for correct RNA metabolism.
Biological function summary

The RNA-binding capabilities of ZCCHC7 impact the maturation of non-coding RNAs such as small nucleolar RNAs (snoRNAs) and ribosomal RNAs (rRNAs). This protein is a component of the TRAMP complex which plays a role in identifying and marking RNA molecules for degradation. By participating in this complex ZCCHC7 helps maintain cellular RNA homeostasis ensuring the production and degradation processes are well-balanced.

Pathways

The TRAMP complex of which ZCCHC7 is a part integrates into the RNA decay pathway and the RNA surveillance pathway. These pathways are critical for eliminating defective RNAs to prevent the synthesis of aberrant proteins. ZCCHC7 works with other proteins in these pathways such as Mtr4 and ZCCHC8 to ensure only properly processed RNAs contribute to gene expression thereby maintaining proteostasis and cellular function.

The proper functioning of ZCCHC7 is important for preventing conditions connected to RNA processing defects. Disruptions in its activity have associations with neurodegenerative diseases and certain cancers as the accumulation of faulty RNAs can lead to abnormal cell behavior. The protein works closely with the nuclear exosome component known as RRP6 in these disorders emphasizing the importance of their joint role in safeguarding RNA quality control.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information ZCCHC7
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of neurology, neurosurgery, and psychiatry 85:92-8 PubMed23667215

2013

Clinical characterisation of Becker muscular dystrophy patients predicts favourable outcome in exon-skipping therapy.

Applications

Unspecified application

Species

Unspecified reactive species

J C van den Bergen,S M Schade van Westrum,L Dekker,A J van der Kooi,M de Visser,B H A Wokke,C S Straathof,M A Hulsker,A Aartsma-Rus,J J Verschuuren,H B Ginjaar
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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