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AB28759

Anti-ZDHHC13 antibody

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(3 Publications)

Goat Polyclonal ZDHHC13 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ZDHHC13 aa 600 to C-terminus.

View Alternative Names

HIP14L, HIP3RP, ZDHHC13, Palmitoyltransferase ZDHHC13, Huntingtin-interacting protein 14-related protein, Huntingtin-interacting protein HIP3RP, Putative MAPK-activating protein PM03, Putative NF-kappa-B-activating protein 209, Zinc finger DHHC domain-containing protein 13, HIP14-related protein, DHHC-13

1 Images
Western blot - Anti-ZDHHC13 antibody (AB28759)
  • WB

Unknown

Western blot - Anti-ZDHHC13 antibody (AB28759)

Primary antibody was incubated for 1 hour.

All lanes:

Western blot - Anti-ZDHHC13 antibody (ab28759) at 0.1 µg/mL

All lanes:

Human cerebellum lysate at 35 µg

Predicted band size: 71 kDa

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Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ZDHHC13 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8IUH4

Specificity

This antibody is expected to recognise both reported isoforms (as represented by NP_061901 and NP_001001483).

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Primary Antibodies

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Anti-O-Linked N-Acetylglucosamine antibody [RL2]

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Primary Antibodies

AB154790

Anti-DHHC-18 antibody [EPR9871]

RabMAb|Recombinant

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  • 0
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Primary Antibodies

AB73938

Anti-5-methylcytosine (5-mC) antibody [5MC-CD]

Immunocytochemistry/ Immunofluorescence - Anti-5-methylcytosine (5-mC) antibody [5MC-CD] (AB73938)

  • 3
  • 2
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-3 µg/mL", "WB-species-notes": "<p>A 1 hour primary incubation is recommended for this product.</p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
This antibody was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 0.5% BSA, 0.5% Tris
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZDHHC13 also known as zinc finger DHHC-type containing 13 is a protein that performs a critical role in protein palmitoylation which is a lipid modification process that involves the addition of palmitate to other proteins. This modification process helps proteins with membrane targeting and function. ZDHHC13 weighs approximately 72 kDa and is primarily distributed in the brain and testes indicating its significant roles in these tissues. The protein's palmitoylation activity regulates protein trafficking stability and interactions making it essential for dynamic cellular processes.
Biological function summary

ZDHHC13 participates in cellular signaling and synaptic function. It can form part of a protein complex that modulates neuronal activity and development influencing neurotransmitter systems and synaptic plasticity. This protein plays an essential role in managing the distribution and function of various other proteins by facilitating their anchoring to cell membranes. Its function impacts excitatory neurotransmitter systems which are significant for maintaining normal cognitive processes.

Pathways

ZDHHC13 engages in pathways such as the Ras-MAPK signaling pathway and modulates signal transduction. These pathways influence cell differentiation proliferation and survival highlighting their importance in cellular activities. ZDHHC13 interacts closely with proteins like Ras and MAP2K affecting downstream signaling mechanisms that govern cell fate decisions. Through these pathways ZDHHC13's enzymatic activity can trigger or inhibit important signaling cascades.

ZDHHC13's dysfunction links to neurodegenerative diseases and cognitive disorders. Aberrations in its palmitoylation activity may lead to conditions like Huntington's disease and Alzheimer's disease. In these contexts ZDHHC13 interacts with proteins such as huntingtin and tau where altered palmitoylation impacts their stability and aggregation. Understanding this protein's role offers insights into potential therapeutic targets for treating neurological conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (By similarity). Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport.
See full target information ZDHHC13
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cancer research 83:1062-1073 PubMed36701140

2023

AMPK Phosphorylates ZDHHC13 to Increase MC1R Activity and Suppress Melanomagenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Sun,Xin Li,Chengqian Yin,Judy Zhang,Ershang Liang,Xianfang Wu,Ying Ni,Joshua Arbesman,Colin R Goding,Shuyang Chen

Nature communications 10:877 PubMed30787281

2019

Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads.

Applications

Unspecified application

Species

Unspecified reactive species

Shuyang Chen,Changpeng Han,Xiao Miao,Xin Li,Chengqian Yin,Junrong Zou,Min Liu,Shanshan Li,Lukasz Stawski,Bo Zhu,Qiong Shi,Zhi-Xiang Xu,Chunying Li,Colin R Goding,Jun Zhou,Rutao Cui

Nature 549:399-403 PubMed28869973

2017

Palmitoylation-dependent activation of MC1R prevents melanomagenesis.

Applications

WB

Species

Unspecified reactive species

Shuyang Chen,Bo Zhu,Chengqian Yin,Wei Liu,Changpeng Han,Baoen Chen,Tongzheng Liu,Xin Li,Xiang Chen,Chunying Li,Limin Hu,Jun Zhou,Zhi-Xiang Xu,Xiumei Gao,Xu Wu,Colin R Goding,Rutao Cui
View all publications
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Product promise

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