Anti-ZFYVE19 antibody [EPR9789]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ZFYVE19 also known as Zinc Finger FYVE-type Containing 19 or ANKFY1 is a protein characterized by the presence of an FYVE domain and ankyrin repeats. This protein has a molecular mass of approximately 104 kDa. ZFYVE19 is expressed broadly in human tissues with high expression levels in the testis brain and heart. Mechanically it plays a pivotal role in vesicular trafficking where the FYVE domain is often involved in binding phosphatidylinositol 3-phosphate on endosomal membranes assisting in the regulation of endosomal-lysosomal sorting.

Biological function summary

This protein plays a significant role in cellular processes related to membrane trafficking and endocytosis. It often participates in protein complexes related to intracellular transport ensuring proper vesicular movements within the cell. ZFYVE19 is known to associate with various molecules that facilitate communication between different cellular compartments. These interactions are essential for cellular homeostasis and affect diverse processes such as signal transduction and nutrient uptake.

Pathways

ZFYVE19 integrates itself in the endosomal-lysosomal pathway and the phosphoinositide signaling pathway. These pathways are important for maintaining cellular lipid homeostasis and endosome maturation. In its function ZFYVE19 interacts with proteins such as EEA1 a well-known early endosome antigen and RAB5A a small GTPase that regulates endocytic vesicle fusion. These interactions help orchestrate the dynamics of membrane trafficking and signal transduction.

Associated diseases and disorders

Disruptions in ZFYVE19 function have been associated with neurodegenerative diseases and certain cancers. In the context of neurodegenerative diseases a malfunction in endosomal-lysosomal sorting can lead to the accumulation of cellular debris similar to defects observed in disorders like Alzheimer's disease. ZFYVE19's interplay with clathrin which is critical for endocytosis can influence tumorigenesis with alterations in this process contributing to oncogenic transformations in some forms of cancer. Understanding the roles played by ZFYVE19 in these diseases provides insight into potential therapeutic targets.