Anti-ZIC4 antibody - C-terminal

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ZIC4 also known as Zinc Finger Protein 4 functions as a transcription factor with a molecular weight of approximately 67 kDa. This protein contains zinc finger motifs which participate in DNA-binding. Researchers have observed ZIC4 expression in the central nervous system particularly during early vertebrate development. Its expression patterns are critical for proper central nervous system formation.

Biological function summary

ZIC4 has a significant role in the regulation of gene expression during embryonic development. It participates in controlling the transcription of genes essential for nervous system formation. ZIC4 interacts with other proteins often as part of multi-protein complexes which can impact its function. This protein’s regulation ensures the correct development of neural tissues affecting both the size and structure of the brain and spinal cord.

Pathways

Researchers position ZIC4 within critical developmental pathways such as the Hedgehog and Wnt signaling pathways. These pathways influence important processes like cell fate determination and patterning. In these pathways ZIC4 interacts with proteins like ZIC1 and ZIC3 which are also zinc finger proteins involved in similar signaling mechanisms. These interactions indicate a network of protein functions that influence early development stages.

Associated diseases and disorders

Researchers associate ZIC4 with Dandy-Walker Malformation and Joubert Syndrome. These are developmental disorders affecting the cerebellum and other parts of the brain. In these conditions mutations or dysfunctions in ZIC4 can disrupt proper neural development leading to the symptoms seen in these syndromes. ZIC proteins like ZIC2 often show relationships in these disorders due to similar functions in neural development.