Rabbit Polyclonal ZIP-10 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human SLC39A10 conjugated to Keyhole Limpet Haemocyanin.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human SLC39A10 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q9ULF5
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 5 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Target data
Function
Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity).
Alternative names
KIAA1265, ZIP10, SLC39A10, Zinc transporter ZIP10, Solute carrier family 39 member 10, Zrt- and Irt-like protein 10, ZIP-10
Recommended products
Rabbit Polyclonal ZIP-10 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human SLC39A10 conjugated to Keyhole Limpet Haemocyanin.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human SLC39A10 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q9ULF5
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ZIP-10 also known as SLC39A10 acts as a zinc transporter which redistributes zinc across cellular membranes. It plays a role in maintaining zinc homeostasis by absorbing zinc from extracellular spaces into the cell. The molecular weight of ZIP-10 is approximately 85 kDa. Expression occurs mainly in kidneys liver and the brain where zinc plays important roles in physiological processes.
- Biological function summary
ZIP-10 regulated zinc uptake influences cellular functions significantly including growth apoptosis and immune responses. It functions as part of the ZIP family of zinc transporters involved in importing zinc into the cell. ZIP-10 works in concert with other zinc transporters and requires coordination with other metal transport systems for effective metal ion equilibrium within the cells.
- Pathways
Zinc transport by ZIP-10 fits into cellular ion homeostasis and signaling pathways. It plays a role in the oxidative stress response pathway and MAPK signaling pathway assisting in signaling transduction related to growth and stress responses. ZIP-10 interacts with related proteins like ZIP1 and ZIP3 within these pathways facilitating cellular adaptation to changes in zinc availability.
- Associated diseases and disorders
ZIP-10 dysregulation has connections to neurological diseases and liver disorders. Elevated or reduced ZIP-10 expression can affect zinc-dependent mechanisms leading to diseases like Alzheimer's disease and nonalcoholic steatohepatitis. It also relates to proteins such as metallothioneins in managing zinc buffering capacity impacting disease progression and severity.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZIP-10 antibody (ab117556)
ab117556, at 5μg/ml, staining ZIP-10 in formalin-fixed, paraffin-embedded Human Kidney tissue by Immunohistochemistry.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZIP-10 antibody (ab117556)
ab117556, at 5μg/ml, staining ZIP-10 in formalin-fixed, paraffin-embedded Human Prostate tissue by Immunohistochemistry.
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