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AB106570

Anti-ZIP-12 antibody

5

(1 Review)

|

(2 Publications)

Rabbit Polyclonal ZIP-12 antibody. Suitable for ICC, WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SLC39A12.

View Alternative Names

ZIP12, SLC39A12, Zinc transporter ZIP12, LIV-1 subfamily of ZIP zinc transporter 8, Solute carrier family 39 member 12, Zrt- and Irt-like protein 12, LZT-Hs8, ZIP-12

1 Images
Western blot - Anti-ZIP-12 antibody (AB106570)
  • WB

Supplier Data

Western blot - Anti-ZIP-12 antibody (AB106570)

Lane 1:

Western blot - Anti-ZIP-12 antibody (ab106570) at 0.5 µg/mL

Lane 2:

Western blot - Anti-ZIP-12 antibody (ab106570) at 1 µg/mL

All lanes:

HepG2 cell lysate at 15 µg

Predicted band size: 76 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Mouse

Applications

ICC, WB, IHC-P, ICC/IF

applications

Immunogen

Synthetic Peptide within Human SLC39A12. The exact immunogen used to generate this antibody is proprietary information.

Q504Y0

Specificity

At least four isoforms of ZIP-12 are known to exist. ab106570 is predicted not to cross-react with other SLC39 family members.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ZIP-12 protein also known as SLC39A12 functions as a zinc transporter regulating zinc homeostasis by importing zinc into cells. This protein weighs approximately 42 kDa and is expressed primarily in the brain with notable presence in neurons. Its role ensures proper zinc levels inside cells which is critical for various cellular functions including enzyme activity and gene expression.
Biological function summary

ZIP-12 facilitates the transportation of zinc an essential trace element into neural cells. It operates as part of the ZIP family of zinc transporters working closely with other family members to maintain zinc balance within the cell. Proper zinc levels are important for neuronal signaling and overall brain health influencing cognitive functions and development.

Pathways

ZIP-12 integrates into important signaling networks such as the MAPK and PI3K-Akt pathways. These pathways important for cell differentiation and proliferation rely on zinc availability to function correctly. ZIP-12’s activity affects proteins like Akt and ERK connecting it to cellular survival and growth mechanisms.

ZIP-12 displays associations with neurological conditions including schizophrenia and Alzheimer's disease. Zinc imbalance influenced by ZIP-12 malfunction leads to disrupted neuronal functions contributing to disease pathology. Proteins like Tau and amyloid-beta within these diseases further intersect with ZIP-12 via shared pathways influencing neuronal health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Uniporter that promotes Zn(2+) import from the extracellular space to the cytoplasm across the cell membrane. The transport activity is temperature dependent. May play a role in neurulation and neurite extension. May play a key role in maintaining intracellular zinc content at levels that reduce the inhibitory effects of rises in oxidative stress on spermatogonia and spermatozoa viability during spermatogenesis.
See full target information SLC39A12
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Biological trace element research : PubMed32776265

2020

Zinc Homeostasis Alters Zinc Transporter Protein Expression in Vascular Endothelial and Smooth Muscle Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Adrian I Abdo,Hai Bac Tran,Sandra Hodge,John F Beltrame,Peter D Zalewski

Scientific reports 7:4901 PubMed28687758

2017

Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers.

Applications

WB, WB

Species

Pig, Human

Mikael Klingeborn,W Michael Dismuke,Nikolai P Skiba,Una Kelly,W Daniel Stamer,Catherine Bowes Rickman
View all publications
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Product promise

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