Rabbit Polyclonal ZIP-13 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SLC39A13.
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Publications
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- Journal of experimental & clinical cancer research : CR 40:1992021Zinc transporter SLC39A13/ZIP13 facilitates the metastasis of human ovarian cancer cells via activating Src/FAK signaling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXinxin Cheng,Jie Wang,Chunling Liu,Tianduo Jiang,Ningzhi Yang,Dan Liu,Huanhuan Zhao,Zhelong XuPubMed 34154618
- Cardiovascular research 117:820-8352020Zinc ameliorates human aortic valve calcification through GPR39 mediated ERK1/2 signalling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZiying Chen,Flora Gordillo-Martinez,Lei Jiang,Pengcheng He,Wanzi Hong,Xuebiao Wei,Katherine A Staines,Vicky E Macrae,Chunxiang Zhang,Danqing Yu,Xiaodong Fu,Dongxing ZhuPubMed 32259211
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human SLC39A13. The exact immunogen used to generate this antibody is proprietary information. Database link Q96H72
Reactivity data
Select an application| WB | IHC-P | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1 µg/mL | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 20 µg/mL | Notes - |
Target data
Function
Functions as a zinc transporter transporting Zn(2+) from the Golgi apparatus to the cytosol and thus influences the zinc level at least in areas of the cytosol (PubMed:21917916, PubMed:23213233). May regulate beige adipocyte differentiation (By similarity).
Alternative names
ZIP13, SLC39A13, Zinc transporter ZIP13, LIV-1 subfamily of ZIP zinc transporter 9, Solute carrier family 39 member 13, Zrt- and Irt-like protein 13, LZT-Hs9, ZIP-13
Recommended products
Rabbit Polyclonal ZIP-13 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SLC39A13.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human SLC39A13. The exact immunogen used to generate this antibody is proprietary information. Database link Q96H72
- Purification technique
- Affinity purification Immunogen
- Specificity
At least two isoforms of ZIP-13 are known to exist; ab106586 will detect both isoforms. ab106586 is predicted to not crossreact with other ZIP family members.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- Up to 12 months
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ZIP-13 also known as Zrt- and Irt-like protein 13 or SLC39A13 is a member of the ZIP family of metal ion transporters. It has a molecular weight of about 34 kDa. ZIP-13 functions by importing zinc and iron into cells therefore maintaining cellular metal ion homeostasis. Researchers have found the expression of ZIP-13 in various tissues including skin bone and connective tissues.
- Biological function summary
ZIP-13 plays an important role in processes such as development and differentiation. It does not work as part of any known complex but facilitates important cellular functions by ensuring the balance of zinc and iron ions necessary for enzymatic and structural roles in cells. The activity of ZIP-13 has significant implications for the synthesis of proteins and signaling pathways that depend on zinc.
- Pathways
ZIP-13 influences important biological cascades including the TGF-beta signaling and BMP signaling pathways which are important for bone and tissue development. ZIP-13 is related to proteins like SMAD4 and BMP receptors through these pathways. By regulating metal ion concentration ZIP-13 indirectly affects downstream elements in these signaling cascades.
- Associated diseases and disorders
ZIP-13 has associations with conditions such as Ehlers-Danlos syndrome and spondylodysplastic types. Mutations or dysregulation in ZIP-13 can lead to abnormalities in connective tissue formation and maintenance. In Ehlers-Danlos syndrome ZIP-13's interaction with proteins involved in collagen synthesis such as COL1A1 is of particular importance contributing to symptomatic presentations in affected individuals.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Western blot - Anti-ZIP-13 antibody (ab106586)
All lanes: Western blot - Anti-ZIP-13 antibody (ab106586) at 1 µg/mL
All lanes: K562 cell lysate at 15 µg
Predicted band size: 39 kDa
Immunocytochemistry/ Immunofluorescence - Anti-ZIP-13 antibody (ab106586)
Immunofluorescence of ZIP-13 in Human spleen tissue with ab106586 at 20 ug/mL.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZIP-13 antibody (ab106586)
Immunohistochemistry of ZIP-13 in Human spleen tissue with ab106586 at 2.5 μg/mL.
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