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AB106586

Anti-ZIP-13 antibody

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(3 Publications)

Rabbit Polyclonal ZIP-13 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SLC39A13.

View Alternative Names

ZIP13, SLC39A13, Zinc transporter ZIP13, LIV-1 subfamily of ZIP zinc transporter 9, Solute carrier family 39 member 13, Zrt- and Irt-like protein 13, LZT-Hs9, ZIP-13

3 Images
Western blot - Anti-ZIP-13 antibody (AB106586)
  • WB

Unknown

Western blot - Anti-ZIP-13 antibody (AB106586)

All lanes:

Western blot - Anti-ZIP-13 antibody (ab106586) at 1 µg/mL

All lanes:

K562 cell lysate at 15 µg

Predicted band size: 39 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZIP-13 antibody (AB106586)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZIP-13 antibody (AB106586)

Immunohistochemistry of ZIP-13 in Human spleen tissue with ab106586 at 2.5 μg/mL.

Immunocytochemistry/ Immunofluorescence - Anti-ZIP-13 antibody (AB106586)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ZIP-13 antibody (AB106586)

Immunofluorescence of ZIP-13 in Human spleen tissue with ab106586 at 20 ug/mL.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human SLC39A13. The exact immunogen used to generate this antibody is proprietary information.

Q96H72

Specificity

At least two isoforms of ZIP-13 are known to exist; ab106586 will detect both isoforms. ab106586 is predicted to not crossreact with other ZIP family members.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZIP-13 also known as Zrt- and Irt-like protein 13 or SLC39A13 is a member of the ZIP family of metal ion transporters. It has a molecular weight of about 34 kDa. ZIP-13 functions by importing zinc and iron into cells therefore maintaining cellular metal ion homeostasis. Researchers have found the expression of ZIP-13 in various tissues including skin bone and connective tissues.
Biological function summary

ZIP-13 plays an important role in processes such as development and differentiation. It does not work as part of any known complex but facilitates important cellular functions by ensuring the balance of zinc and iron ions necessary for enzymatic and structural roles in cells. The activity of ZIP-13 has significant implications for the synthesis of proteins and signaling pathways that depend on zinc.

Pathways

ZIP-13 influences important biological cascades including the TGF-beta signaling and BMP signaling pathways which are important for bone and tissue development. ZIP-13 is related to proteins like SMAD4 and BMP receptors through these pathways. By regulating metal ion concentration ZIP-13 indirectly affects downstream elements in these signaling cascades.

ZIP-13 has associations with conditions such as Ehlers-Danlos syndrome and spondylodysplastic types. Mutations or dysregulation in ZIP-13 can lead to abnormalities in connective tissue formation and maintenance. In Ehlers-Danlos syndrome ZIP-13's interaction with proteins involved in collagen synthesis such as COL1A1 is of particular importance contributing to symptomatic presentations in affected individuals.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Functions as a zinc transporter transporting Zn(2+) from the Golgi apparatus to the cytosol and thus influences the zinc level at least in areas of the cytosol (PubMed : 21917916, PubMed : 23213233). May regulate beige adipocyte differentiation (By similarity).
See full target information SLC39A13
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of experimental & clinical cancer research : CR 40:199 PubMed34154618

2021

Zinc transporter SLC39A13/ZIP13 facilitates the metastasis of human ovarian cancer cells via activating Src/FAK signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xinxin Cheng,Jie Wang,Chunling Liu,Tianduo Jiang,Ningzhi Yang,Dan Liu,Huanhuan Zhao,Zhelong Xu

Cardiovascular research 117:820-835 PubMed32259211

2020

Zinc ameliorates human aortic valve calcification through GPR39 mediated ERK1/2 signalling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Ziying Chen,Flora Gordillo-Martinez,Lei Jiang,Pengcheng He,Wanzi Hong,Xuebiao Wei,Katherine A Staines,Vicky E Macrae,Chunxiang Zhang,Danqing Yu,Xiaodong Fu,Dongxing Zhu

Cell death & disease 10:645 PubMed31501417

2019

TM4SF5-mediated CD44v8-10 splicing variant promotes survival of type II alveolar epithelial cells during idiopathic pulmonary fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Ji Eon Kim,Hye-Jin Kim,Jae Woo Jung,Dae-Geun Song,Dasomi Park,Haesong Lee,Hyejin Um,Jinsoo Park,Seo Hee Nam,Moonjae Cho,Jung Weon Lee
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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