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AB117568

Anti-ZIP-3 antibody

4

(1 Review)

|

(2 Publications)

Rabbit Polyclonal ZIP-3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SLC39A3 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

ZIP3, SLC39A3, Zinc transporter ZIP3, Solute carrier family 39 member 3, Zrt- and Irt-like protein 3, ZIP-3

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZIP-3 antibody (AB117568)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZIP-3 antibody (AB117568)

ab117568, at 5 μg/ml, staining ZIP-3 in formalin fixed, paraffin embedded Human testis tissue by Immunohistochemistry.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZIP-3 antibody (AB117568)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZIP-3 antibody (AB117568)

ab117568, at 5 μg/ml, staining ZIP-3 in formalin fixed, paraffin embedded Human prostate tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human SLC39A3 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9BRY0

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Alternative Products

Primary Antibodies

AB254868

Anti-ZIP-3 antibody

Western blot - Anti-ZIP-3 antibody (AB254868)

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Complementary Products

Primary Antibodies

AB105194

Anti-ZIP-5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZIP-5 antibody (AB105194)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Primary Antibodies

AB214356

Anti-ZnT1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZnT1 antibody (AB214356)

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Primary Antibodies

AB254839

Anti-SERP1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SERP1 antibody (AB254839)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZIP-3 also known as SLC39A3 is a protein that functions as a zinc transporter facilitating the uptake of zinc into cells. This protein belongs to the solute carrier (SLC) family and typically has a mass of approximately 47 kDa. ZIP-3 localizes mainly to the plasma membrane and is expressed in a variety of tissues including liver kidney and intestine. It plays an important role in maintaining intracellular zinc homeostasis critical for various cellular functions.
Biological function summary

Zinc is essential for numerous cellular processes and ZIP-3 helps regulate its availability. Zinc acts as a cofactor for over 300 enzymes and plays a vital role in transcription factor function gene expression and cell signaling. Through these actions ZIP-3 impacts cellular proliferation differentiation and survival. ZIP-3 does not form part of a larger complex but works closely with other zinc transporters such as those from the ZIP and ZnT families to balance zinc levels in the body.

Pathways

Researchers have associated ZIP-3 with critical processes such as the metal ion transport and cellular response to stress. By modulating zinc levels ZIP-3 interacts with pathways like the MAPK signaling pathway which is pivotal for cell growth and division. In these pathways ZIP-3 operates alongside proteins like ZIP-4 and ZnT-1 ensuring proper zinc redistribution and cellular adaptation to changing environmental conditions.

Scientists have linked ZIP-3 dysfunction to conditions such as type 2 diabetes and neurodegenerative disorders. Abnormal ZIP-3 activity can disrupt zinc homeostasis contributing to insulin resistance in diabetes. In neurodegenerative diseases impaired zinc transport by ZIP-3 can lead to neuronal damage and cognitive deficits. Research also examines the interplay of ZIP-3 with other proteins such as insulin receptor substrate (IRS) in diabetes highlighting the potential for targeted therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus. Mediates Zn(2+) reuptake from the secreted milk within the alveolar lumen.
See full target information SLC39A3
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 42:2824-2834 PubMed35169020

2022

The ZIP3 Zinc Transporter Is Localized to Mossy Fiber Terminals and Is Required for Kainate-Induced Degeneration of CA3 Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Milos Bogdanovic,Hila Asraf,Noa Gottesman,Israel Sekler,Elias Aizenman,Michal Hershfinkel

PloS one 11:e0153262 PubMed27064487

2016

Rett Syndrome Mutant Neural Cells Lacks MeCP2 Immunoreactive Bands.

Applications

Unspecified application

Species

Unspecified reactive species

Carlos Bueno,Rafael Tabares-Seisdedos,Jose M Moraleda,Salvador Martinez
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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