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AB230099

Anti-ZIP-4 antibody

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(2 Publications)

Rabbit Polyclonal ZIP-4 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC39A4 aa 1-350.

View Alternative Names

ZIP4, SLC39A4, Zinc transporter ZIP4, Solute carrier family 39 member 4, Zrt- and Irt-like protein 4, ZIP-4

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZIP-4 antibody (AB230099)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZIP-4 antibody (AB230099)

Paraffin-embedded human kidney tissue stained for ZIP-4 using ab230099 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-ZIP-4 antibody (AB230099)
  • WB

Supplier Data

Western blot - Anti-ZIP-4 antibody (AB230099)

All lanes:

Western blot - Anti-ZIP-4 antibody (ab230099) at 1/1000 dilution

Lane 1:

Mouse stomach lysate

Lane 2:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 68 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SLC39A4 aa 1-350. The exact immunogen used to generate this antibody is proprietary information.

Q6P5W5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZIP-4 also known as SLC39A4 functions as a zinc transporter responsible for the uptake of zinc ions from the extracellular space into the cytoplasm. It plays a critical role in maintaining zinc homeostasis within the cell. The protein has a molecular mass of approximately 67 kDa. ZIP-4 is predominantly expressed in the small intestine and pancreas where it regulates zinc absorption important for various biological processes.
Biological function summary

ZIP-4 influences the cellular zinc levels by facilitating zinc influx across the plasma membrane. This transport ensures adequate zinc supply for enzymatic reactions and cellular functions. ZIP-4 does not operate as part of a larger complex but acts independently to regulate zinc entry which impacts cell signaling immune responses and cell proliferation.

Pathways

ZIP-4 participates in the regulation of zinc-dependent pathways such as the MAPK signaling pathway and the NF-kB signaling pathway. These pathways are essential for cell growth survival and immune response. ZIP-4 interacts with other transporters like ZIP-1 and ZIP-10 contributing significantly to the intricate network of zinc homeostasis and cellular regulation.

Abnormal ZIP-4 function has links to acrodermatitis enteropathica a rare genetic disorder caused by impaired zinc absorption. This condition causes skin lesions immune dysfunctions and developmental issues. Additionally dysregulation of ZIP-4 has been implicated in certain cancers where increased ZIP-4 expression correlates with tumor growth and metastasis highlighting its relevance in disease pathology and potential as a therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Selective transporter that mediates the uptake of Zn(2+) (PubMed : 17202136, PubMed : 22242765, PubMed : 27321477, PubMed : 28875161, PubMed : 31164399, PubMed : 31914589, PubMed : 31979155, PubMed : 33837739, PubMed : 36473915). Plays an essential role for dietary zinc uptake from small intestine (By similarity). The Zn(2+) uniporter activity is regulated by zinc availability (PubMed : 17202136, PubMed : 32348750). Exhibits also polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (PubMed : 22242765, PubMed : 31914589).
See full target information SLC39A4
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nutrients 16: PubMed39599720

2024

Dietary Zinc Restriction and Chronic Restraint Stress Affect Mice Physiology, Immune Organ Morphology, and Liver Function.

Applications

Unspecified application

Species

Unspecified reactive species

Dorota Bederska-Łojewska,Kinga Szczepanik,Justyna Turek,Agata Machaczka,Łukasz Gąsior,Bartłomiej Pochwat,Joanna Piotrowska,Bartłomiej Rospond,Bernadeta Szewczyk

Aging 16:11668-11682 PubMed39133152

2024

Solamargine acts as an antiviral by interacting to MZF1 and targeting the core promoter of the hepatitis B virus gene.

Applications

Unspecified application

Species

Unspecified reactive species

Wenwen Chen,Xinrui Zhao,Yingli Huang,Kai Lu,Yuan Li,Xiaofang Li,Hui Ding,Xiuling Li,Suofeng Sun
View all publications
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