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AB187866

Anti-ZKSCAN3 antibody

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(3 Publications)

Rabbit Polyclonal ZKSCAN3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZKSCAN3 aa 150-300.

View Alternative Names

ZFP47, ZNF306, ZNF309, ZSCAN13, ZKSCAN3, Zinc finger protein with KRAB and SCAN domains 3, Zinc finger and SCAN domain-containing protein 13, Zinc finger protein 306, Zinc finger protein 309, Zinc finger protein 47 homolog, Zf47, Zfp-47

6 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZKSCAN3 antibody (AB187866)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZKSCAN3 antibody (AB187866)

Immunohistochemical analysis of human prostate tissue labelled for ZKSCAN3 using ab187866. Positive nuclear and cytoplasmic staining observed in glandular cells.

Immunocytochemistry/ Immunofluorescence - Anti-ZKSCAN3 antibody (AB187866)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ZKSCAN3 antibody (AB187866)

Immunofluorescent analysis of Human cell line A-431 labeling ZKSCAN3 with ab187866 at 4μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZKSCAN3 antibody (AB187866)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZKSCAN3 antibody (AB187866)

Immunohistochemical analysis of human placenta tissue labelled for ZKSCAN3 using ab187866. Positive nuclear and cytoplasmic staining observed in trophoblastic cells.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZKSCAN3 antibody (AB187866)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZKSCAN3 antibody (AB187866)

Immunohistochemical analysis of human small intestine tissue labelled for ZKSCAN3 using ab187866. Strong positive nuclear staining observed in glandular cells.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZKSCAN3 antibody (AB187866)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZKSCAN3 antibody (AB187866)

Immunohistochemical analysis of human cervical cancer tissue labelled for ZKSCAN3 using ab187866. Positive nuclear staining observed in tumor cells.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZKSCAN3 antibody (AB187866)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZKSCAN3 antibody (AB187866)

Immunohistochemical analysis of human tonsil tissue labelled for ZKSCAN3 using ab187866. Positive nuclear staining observed in germinal and non-germinal center cells.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ZKSCAN3 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.

Q9BRR0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZKSCAN3 also known as Zinc finger protein with KRAB and SCAN domains 3 is a transcription factor with an approximate mass of 95 kDa. It contains zinc finger motifs that bind to DNA influencing the transcription of specific genes. ZKSCAN3 is expressed in various tissues with high levels noted in the kidney liver and lung. It plays a role in gene regulation by modulating transcriptional responses making it an important factor in cellular function.
Biological function summary

ZKSCAN3 impacts cellular processes and functions as a transcriptional suppressor. ZKSCAN3 has been identified as part of certain protein complexes that interact with chromatin remodelers and co-regulators. This interaction helps in regulating gene expression critical for cell growth and development. Its activity influences various biological processes including cell cycle progression and apoptosis highlighting its role in maintaining cellular homeostasis.

Pathways

ZKSCAN3 serves functions in the autophagy and Wnt signaling pathways. Within the autophagy pathway it negatively regulates autophagic activity impacting cellular homeostasis and survival under stress conditions. ZKSCAN3 is related to proteins like LC3 and p62 which are significant in this pathway. Its interaction within the Wnt signaling pathway contributes to the regulation of gene expression related to proliferation and differentiation with beta-catenin as a notable interacting protein.

ZKSCAN3 shows implications in cancer and neurodegenerative diseases. In cancers its overexpression correlates with tumor progression and poor prognosis often through interaction with proteins such as MYC and mTOR which promote cancer cell survival. Regarding neurodegenerative disorders alterations in ZKSCAN3 expression influence pathways linked with neuronal survival and autophagy affecting disease mechanisms in disorders such as Alzheimer’s disease. These connections make ZKSCAN3 an interesting target for therapeutic research.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.
See full target information ZKSCAN3
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Nucleic acids research 53: PubMed40705926

2025

PPARG-centric transcriptional re-wiring during differentiation of human trophoblast stem cells into extravillous trophoblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Qingqing Guo,Joonhyuk Choi,Muyoung Lee,Jonghwan Kim

Cancer science 115:1964-1978 PubMed38671550

2024

Expression of ZKSCAN3 protein suppresses proliferation, migration, and invasion of pancreatic cancer through autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Keisuke Nonoyama,Yoichi Matsuo,Saburo Sugita,Yuki Eguchi,Yuki Denda,Hiromichi Murase,Tomokatsu Kato,Hiroyuki Imafuji,Kenta Saito,Mamoru Morimoto,Ryo Ogawa,Hiroki Takahashi,Akira Mitsui,Masahiro Kimura,Shuji Takiguchi

Anticancer research 40:81-86 PubMed31892555

2020

Prognostic Significance of ZKSCAN3 (ZNF306) Expression in Gastric Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yuta Takano,Atsuo Shida,Muneharu Fujisaki,Norio Mitsumori,Katsuhiko Yanaga
View all publications
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Product promise

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