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AB235355

Anti-ZMAT5 antibody

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(1 Publication)

Rabbit Polyclonal ZMAT5 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ZMAT5.

View Alternative Names

Zinc finger matrin-type protein 5, U11/U12 small nuclear ribonucleoprotein 20 kDa protein, U11/U12 snRNP 20 kDa protein, U11/U12-20K, ZMAT5

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZMAT5 antibody (AB235355)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZMAT5 antibody (AB235355)

Paraffin-embedded human tonsil tissue stained for ZMAT5 using ab235355 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZMAT5 antibody (AB235355)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZMAT5 antibody (AB235355)

Paraffin-embedded human endometrial cancer tissue stained for ZMAT5 using ab235355 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-ZMAT5 antibody (AB235355)
  • WB

Supplier Data

Western blot - Anti-ZMAT5 antibody (AB235355)

All lanes:

Western blot - Anti-ZMAT5 antibody (ab235355) at 1/500 dilution

All lanes:

COLO 320 (Human colon adenocarcinoma cell line) whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 20 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ZMAT5.

Q9UDW3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZMAT5 also known as zinc finger matrin-type 5 is a protein that functions primarily by binding nucleic acids. It has a molecular mass of approximately 57 kDa. ZMAT5 contains zinc finger motifs which enable it to interact with RNA and possibly DNA suggesting a role in post-transcriptional regulation. It is mainly expressed in the nucleus of cells with significant expression reported in various tissues including the brain heart and liver.
Biological function summary

ZMAT5 plays a role in regulating mRNA stability and splicing. It may form part of a larger ribonucleoprotein complex interacting with other proteins and RNA to influence gene expression at a post-transcriptional level. The binding of ZMAT5 to specific RNA sequences indicates specialized functions which can affect how cells respond to different conditions by altering how genes are expressed.

Pathways

The presence of ZMAT5 is significant in RNA-related pathways including the regulation of mRNA splicing. Within these pathways it interacts with spliceosome components which are important for the precise removal of introns from pre-mRNA. ZMAT5 may influence the activity of related proteins like SRSF1 and hnRNPA1 which are key players in the splicing mechanism and control diverse cellular processes.

Research links ZMAT5 with neurodegenerative disorders and certain cancers. Abnormalities in its splicing functions can relate to diseases like amyotrophic lateral sclerosis (ALS) where disrupted RNA processing is a common hallmark. Furthermore dysregulation of ZMAT5 expression or function could connect with cancer progression involving proteins like SRSF6 which modulate similar pathways and are often deregulated in tumors.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information ZMAT5
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical endocrinology and metabolism 107:3328-3340 PubMed36074910

2022

Premature Ovarian Insufficiency in CLPB Deficiency: Transcriptomic, Proteomic and Phenotypic Insights.

Applications

Unspecified application

Species

Unspecified reactive species

Elena J Tucker,Megan J Baker,Daniella H Hock,Julia T Warren,Sylvie Jaillard,Katrina M Bell,Rajini Sreenivasan,Shabnam Bakhshalizadeh,Chloe A Hanna,Nikeisha J Caruana,Saskia B Wortmann,Shamima Rahman,Robert D S Pitceathly,Jean Donadieu,Aurelia Alimi,Vincent Launay,Paul Coppo,Sophie Christin-Maitre,Gorjana Robevska,Jocelyn van den Bergen,Brianna L Kline,Katie L Ayers,Phoebe N Stewart,David A Stroud,Diana Stojanovski,Andrew H Sinclair
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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