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AB113277

Anti-ZMIZ2 antibody

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(1 Publication)

Rabbit Polyclonal ZMIZ2 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZMIZ2.

View Alternative Names

KIAA1886, ZIMP7, HRIHFB2007, ZMIZ2, Zinc finger MIZ domain-containing protein 2, PIAS-like protein Zimp7

1 Images
Western blot - Anti-ZMIZ2 antibody (AB113277)
  • WB

Unknown

Western blot - Anti-ZMIZ2 antibody (AB113277)

Lane 1:

Western blot - Anti-ZMIZ2 antibody (ab113277) at 0.25 µg/mL

Lane 2:

Western blot - Anti-ZMIZ2 antibody (ab113277) at 0.5 µg/mL

All lanes:

A20 cell lysate at 15 µg

Predicted band size: 97 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ZMIZ2. The exact immunogen used to generate this antibody is proprietary information.

Q8NF64

Specificity

ab113277 is predicted to not cross-react with other ZMIZ protein family members.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.25-0.5 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab113277 is purified by affinity chromatography via a peptide column.
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZMIZ2 also known as Zinc Finger MIZ-Type Containing 2 is a transcriptional co-activator. It has a molecular mass of about 130-150 kDa determined by its sequence and glycosylation state. ZMIZ2 localizes primarily in the nucleus and exhibits expression in various tissues with notable levels in the testis brain and skin. The protein contains a zinc finger domain which allows it to interact with other transcription factors and plays a role in the regulation of gene expression.
Biological function summary

ZMIZ2 participates in the modulation of transcription by interacting with other proteins. It does not act alone but often associates with protein complexes enhancing the transcriptional activity of steroid hormone receptors such as the androgen receptor. ZMIZ2 influences the transcription of genes essential for cell proliferation and differentiation. This function underlines its importance in developmental processes and cellular growth.

Pathways

ZMIZ2 contributes to the regulation of signaling pathways like the androgen receptor signaling pathway and the Wnt signaling pathway. In these pathways ZMIZ2 acts together with proteins like β-catenin in the Wnt pathway to regulate gene expression. The coordination with androgen receptor involves modulation of genes important for cellular responses to hormones impacting various physiological processes including reproduction and hair growth.

Mutations or dysregulation in ZMIZ2 have associations with prostate cancer and melanoma. In prostate cancer ZMIZ2 enhances androgen receptor signaling which is critical for cancer progression. Connections with BRCA1 in breast cancer also implicate its larger role in chromatin remodeling and DNA repair processes. In melanoma ZMIZ2's involvement in cell proliferation pathways suggests its participation in tumor growth and metastasis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.
See full target information ZMIZ2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Breast cancer research : BCR 24:79 PubMed36376977

2022

Androgen receptor function and targeted therapeutics across breast cancer subtypes.

Applications

Unspecified application

Species

Unspecified reactive species

Emily A Kolyvas,Carlos Caldas,Kathleen Kelly,Saif S Ahmad
View all publications
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Product promise

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