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AB84507

Anti-ZMYM3 antibody

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(2 Publications)

Rabbit Polyclonal ZMYM3 antibody. Suitable for IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ZMYM3.

View Alternative Names

DXS6673E, KIAA0385, ZNF261, ZMYM3, Zinc finger MYM-type protein 3, Zinc finger protein 261

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZMYM3 antibody (AB84507)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZMYM3 antibody (AB84507)

Detection of Human ZMYM3 by Immunohistochemistry on paraffin embedded formalin fixed section of Human breast adenocarcinoma using 1/250 ab84507. Detection : DAB staining

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZMYM3 antibody (AB84507)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZMYM3 antibody (AB84507)

Detection of Human ZMYM3 by Immunohistochemistry on paraffin embedded formalin fixed section of Human ovarian carcinoma using 1/250 ab84507. Detection : DAB staining

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZMYM3 antibody (AB84507)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZMYM3 antibody (AB84507)

Detection of Mouse ZMYM3 by Immunohistochemistry on paraffin embedded formalin fixed section of Mouse teratoma using 1/250 ab84507. Detection : DAB staining

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human ZMYM3. The exact immunogen used to generate this antibody is proprietary information.

Q14202

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.</p>" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.</p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Ferret": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Guinea pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rhesus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZMYM3 also known as Zinc Finger MYM-Type Containing 3 is a protein with a molecular mass of about 155 kDa. It acts as a transcriptional regulator by binding to specific DNA sequences through its zinc-finger domains. ZMYM3 is mainly expressed in the brain and testes suggesting its role in neural and reproductive functions. The protein localizes primarily in the nucleus where it interacts with chromatin to modulate the expression of target genes.
Biological function summary

There are multiple roles of ZMYM3 in cellular processes. It is part of the CoREST complex a multiprotein scaffold involved in transcriptional repression. Through its participation in this complex ZMYM3 contributes to chromatin remodeling and epigenetic silencing of genes playing a role in maintaining the balance of gene expression necessary for normal cellular operations and development.

Pathways

There are several ways ZMYM3 impacts cellular communication and regulation. The protein is involved in the Notch signaling pathway which is important for cell differentiation proliferation and apoptotic processes. ZMYM3 influences this pathway alongside related proteins such as CoREST and LSD1. Additionally it interacts within the androgen receptor signaling pathway potentially impacting gene transcription relevant to sexual development and hormone response.

There is significant interest in the connection between ZMYM3 and cognitive impairments including X-linked intellectual disability. Mutations or dysregulation in ZMYM3 can lead to disrupted transcriptional control linking the protein to neurological disorders. Another medical condition linked to ZMYM3 is prostate cancer where it may affect androgen receptor pathways thereby implicating interactions with proteins like LSD1 and the androgen receptor itself in the disease's progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in the regulation of cell morphology and cytoskeletal organization.
See full target information ZMYM3
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Acta histochemica et cytochemica 54:143-153 PubMed34764523

2021

ZMYM3 May Promote Cell Proliferation in Small Cell Lung Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Noritaka Kudo,Shinji Kudoh,Akira Matsuo,Yamato Motooka,Takaaki Ito

Nature medicine 18:774-82 PubMed22504483

2012

Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia.

Applications

Unspecified application

Species

Unspecified reactive species

Tobias Eckle,Katherine Hartmann,Stephanie Bonney,Susan Reithel,Michel Mittelbronn,Lori A Walker,Brian D Lowes,Jun Han,Christoph H Borchers,Peter M Buttrick,Douglas J Kominsky,Sean P Colgan,Holger K Eltzschig
View all publications
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Product promise

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