Anti-ZNF169 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ZNF169 also known as Zinc Finger Protein 169 is a transcription factor that belongs to the zinc finger family. This protein weighs about 84 kDa. It functions by binding to specific DNA sequences regulating gene expression. Expression of ZNF169 is found in various tissues including the brain and testes. It plays a role in numerous cellular processes due to its ability to modulate transcription.

Biological function summary

This protein acts as a regulatory element in cellular differentiation and proliferation. It does not form part of a larger protein complex but influences the expression of genes involved in these processes. ZNF169 impacts cellular responses to environmental changes by regulating genes necessary for cell cycle progression and differentiation.

Pathways

Several pathways involve ZNF169 in cell signaling and gene regulation. One important pathway is the DNA damage response pathway where it interacts with proteins like p53 which mediates cell cycle arrest or apoptosis. Another is the WNT signaling pathway related to its role in cellular proliferation and differentiation. ZNF169's influence on these pathways highlights its involvement in maintaining cellular dynamics and stability.

Associated diseases and disorders

Scientists have associated ZNF169 with cancer and intellectual disability conditions. Overexpression or dysregulation of ZNF169 has been linked to tumorigenesis often interacting with proteins like p53 that importantly determine cell fate after DNA damage. In intellectual disabilities abnormal expression of ZNF169 affects genes essential for proper neurological function implicating its role in cognitive development.