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AB246912

Anti-ZNF179/BFP antibody

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(2 Publications)

Rabbit Polyclonal ZNF179/BFP antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RNF112 aa 400-550.

View Alternative Names

BFP, ZNF179, RNF112, RING finger protein 112, Brain finger protein, Zinc finger protein 179

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-ZNF179/BFP antibody (AB246912)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ZNF179/BFP antibody (AB246912)

PFA fixed, Triton X-100 permeabilized SH-SY5Y (Human neuroblastoma cell line from bone marrow) cells labeling ZNF179/BFP using ab246912 at 4 μg/ml (green) in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF179/BFP antibody (AB246912)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF179/BFP antibody (AB246912)

Paraffin-embedded human cerebellum tissue stained for ZNF179/BFP using ab246912 at 1/500 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human RNF112 aa 400-550. The exact immunogen used to generate this antibody is proprietary information.

Q9ULX5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ZNF179/BFP also known as ZNF312 is a zinc finger protein that acts as a transcriptional regulator. It has a molecular weight of approximately 64 kDa. This protein is mostly expressed in the brain especially in the regions related to cognitive function and memory. ZNF179/BFP contains several C2H2-type zinc finger motifs that enable it to bind to DNA and regulate the expression of target genes.
Biological function summary

ZNF179/BFP functions in neuron development and differentiation. It serves as an important element in chromatin remodeling and acts within a transcriptional complex. This action helps modulate the expression of genes involved in neuronal processes. By regulating these genes ZNF179/BFP influences neurogenesis and synaptic plasticity which are essential for proper brain function.

Pathways

ZNF179/BFP plays a role in neural differentiation and repair processes. It contributes to the neural developmental pathway and interacts closely with other proteins such as REST and CTBP1. These interactions help to fine-tune gene expression during critical stages of brain development and respond to neural damage.

Dysfunctional ZNF179/BFP expression links to neurodegenerative diseases like Alzheimer's and schizophrenia. Altered levels of this protein can also affect the expression of the amyloid precursor protein (APP) which is associated with Alzheimer's pathology. In schizophrenia modifications in neural development and receptor expression often associated with REST suggest a connection with ZNF179/BFP's regulatory roles.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins (PubMed : 28684796). Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density (By similarity).
See full target information RNF112
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 27: PubMed37144506

2023

MAGL regulates synovial macrophage polarization vis inhibition of mitophagy in osteoarthritic pain.

Applications

Unspecified application

Species

Unspecified reactive species

Chengyong Gu,Mo Chen,Xueyan Li,Dechun Geng,Chen Wang

Neuropathology : official journal of the Japanese Society of Neuropathology 42:488-504 PubMed35701899

2022

Praja1 RING-finger E3 ubiquitin ligase is a common suppressor of neurodegenerative disease-associated protein aggregation.

Applications

Unspecified application

Species

Unspecified reactive species

Kazuhiko Watabe,Motoko Niida-Kawaguchi,Mari Tada,Yoichiro Kato,Makiko Murata,Kunikazu Tanji,Koichi Wakabayashi,Mitsunori Yamada,Akiyoshi Kakita,Noriyuki Shibata
View all publications
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Product promise

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