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Rabbit Polyclonal ZNF277 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF277 aa 50 to C-terminus.

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Images

Western blot - Anti-ZNF277 antibody (AB96299), expandable thumbnail

Publications

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Form
Liquid
Clonality
Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human ZNF277 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NRM2

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested
Mouse
Predicted
Cow
Predicted

Tested
Tested

Species
Human
Dilution info
1/500 - 1/3000
Notes

-

Predicted
Predicted

Species
Mouse, Cow
Dilution info
-
Notes

-

Target data

Function

Probable transcription factor. Involved in modulation of cellular senescence; represses transcription of the tumor suppressor gene INK4A/ARF, perhaps acting via the Polycomb group (PcG) complex PRC1.

Alternative names

Recommended products

Rabbit Polyclonal ZNF277 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF277 aa 50 to C-terminus.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Polyclonal
Immunogen
  • Recombinant Fragment Protein within Human ZNF277 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NRM2
Purification technique
Affinity purification Immunogen
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

ZNF277 also known as zinc finger protein 277 is a protein that functions mechanically by binding DNA through its zinc finger domains. The exact molecular mass varies but is commonly around 60 kDa. ZNF277 finds expression in various tissues showing higher levels in the brain and testis. It functions as a transcription factor by interacting with specific genes which suggests a role in regulating gene expression.

Biological function summary

The function of ZNF277 involves modulating transcriptional activities. It is not known to be part of a major multi-protein complex but it may interact with other regulatory proteins at the cellular level. This activity influences processes like cell differentiation and development. Mechanisms of how it selects target genes or interacts with chromatin are still under investigation but it possibly involves modification of DNA accessibility.

Pathways

ZNF277 influences transcriptional regulation pathways that control cellular differentiation and neural development. It shares interactions with proteins involved in these pathways like CREB and ELK1 which are essential transcription factors. While ZNF277 is not part of any specific signaling pathway its expression indirectly affects multiple biological processes important for cell identity and function.

Associated diseases and disorders

Changes in ZNF277 expression or mutations can lead to neurodevelopmental disorders. Some studies have linked it to intellectual disabilities suggesting that dysregulation affects cognitive function. It also connects to neuroprotective pathways where proteins like MECP2 often associated with Rett syndrome may interact or be affected by ZNF277 activity. Understanding these interactions helps in understanding the genetic basis of such conditions.

Product promise

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1 product image

  • Western blot - Anti-ZNF277 antibody (ab96299), expandable thumbnail

    Western blot - Anti-ZNF277 antibody (ab96299)

    All lanes: Western blot - Anti-ZNF277 antibody (ab96299) at 1/1000 dilution

    All lanes: 293T whole cell lysate at 30 µg

    Predicted band size: 53 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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