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AB96299

Anti-ZNF277 antibody

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(1 Publication)

Rabbit Polyclonal ZNF277 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF277 aa 50 to C-terminus.

View Alternative Names

NRIF4, ZNF277P, ZNF277, Zinc finger protein 277, Nuclear receptor-interacting factor 4

1 Images
Western blot - Anti-ZNF277 antibody (AB96299)
  • WB

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Western blot - Anti-ZNF277 antibody (AB96299)

All lanes:

Western blot - Anti-ZNF277 antibody (ab96299) at 1/1000 dilution

All lanes:

293T whole cell lysate at 30 µg

Predicted band size: 53 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human ZNF277 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9NRM2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF277 also known as zinc finger protein 277 is a protein that functions mechanically by binding DNA through its zinc finger domains. The exact molecular mass varies but is commonly around 60 kDa. ZNF277 finds expression in various tissues showing higher levels in the brain and testis. It functions as a transcription factor by interacting with specific genes which suggests a role in regulating gene expression.
Biological function summary

The function of ZNF277 involves modulating transcriptional activities. It is not known to be part of a major multi-protein complex but it may interact with other regulatory proteins at the cellular level. This activity influences processes like cell differentiation and development. Mechanisms of how it selects target genes or interacts with chromatin are still under investigation but it possibly involves modification of DNA accessibility.

Pathways

ZNF277 influences transcriptional regulation pathways that control cellular differentiation and neural development. It shares interactions with proteins involved in these pathways like CREB and ELK1 which are essential transcription factors. While ZNF277 is not part of any specific signaling pathway its expression indirectly affects multiple biological processes important for cell identity and function.

Changes in ZNF277 expression or mutations can lead to neurodevelopmental disorders. Some studies have linked it to intellectual disabilities suggesting that dysregulation affects cognitive function. It also connects to neuroprotective pathways where proteins like MECP2 often associated with Rett syndrome may interact or be affected by ZNF277 activity. Understanding these interactions helps in understanding the genetic basis of such conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probable transcription factor. Involved in modulation of cellular senescence; represses transcription of the tumor suppressor gene INK4A/ARF, perhaps acting via the Polycomb group (PcG) complex PRC1.
See full target information ZNF277
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

OncoTargets and therapy 12:3031-3042 PubMed31114246

2019

ZNF277 regulates ovarian cancer cell proliferation and invasion through inhibition of PTEN.

Applications

Unspecified application

Species

Unspecified reactive species

Zhengling Liu,Zonglan Xu,Yonghui Tian,Hua Yan,Yanyan Lou
View all publications
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Product promise

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