Rabbit Polyclonal ZNF277 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF277 aa 50 to C-terminus.
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
WB | |
---|---|
Human | Tested |
Mouse | Predicted |
Cow | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500 - 1/3000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Cow | Dilution info - | Notes - |
Probable transcription factor. Involved in modulation of cellular senescence; represses transcription of the tumor suppressor gene INK4A/ARF, perhaps acting via the Polycomb group (PcG) complex PRC1.
NRIF4, ZNF277P, ZNF277, Zinc finger protein 277, Nuclear receptor-interacting factor 4
Rabbit Polyclonal ZNF277 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF277 aa 50 to C-terminus.
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
ZNF277 also known as zinc finger protein 277 is a protein that functions mechanically by binding DNA through its zinc finger domains. The exact molecular mass varies but is commonly around 60 kDa. ZNF277 finds expression in various tissues showing higher levels in the brain and testis. It functions as a transcription factor by interacting with specific genes which suggests a role in regulating gene expression.
The function of ZNF277 involves modulating transcriptional activities. It is not known to be part of a major multi-protein complex but it may interact with other regulatory proteins at the cellular level. This activity influences processes like cell differentiation and development. Mechanisms of how it selects target genes or interacts with chromatin are still under investigation but it possibly involves modification of DNA accessibility.
ZNF277 influences transcriptional regulation pathways that control cellular differentiation and neural development. It shares interactions with proteins involved in these pathways like CREB and ELK1 which are essential transcription factors. While ZNF277 is not part of any specific signaling pathway its expression indirectly affects multiple biological processes important for cell identity and function.
Changes in ZNF277 expression or mutations can lead to neurodevelopmental disorders. Some studies have linked it to intellectual disabilities suggesting that dysregulation affects cognitive function. It also connects to neuroprotective pathways where proteins like MECP2 often associated with Rett syndrome may interact or be affected by ZNF277 activity. Understanding these interactions helps in understanding the genetic basis of such conditions.
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All lanes: Western blot - Anti-ZNF277 antibody (ab96299) at 1/1000 dilution
All lanes: 293T whole cell lysate at 30 µg
Predicted band size: 53 kDa
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