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AB117769

Anti-ZNF292 antibody

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(1 Publication)

Rabbit Polyclonal ZNF292 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZNF292 aa 2000-2050.

View Alternative Names

KIAA0530, ZNF292, Zinc finger protein 292

1 Images
Immunoprecipitation - Anti-ZNF292 antibody (AB117769)
  • IP

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Immunoprecipitation - Anti-ZNF292 antibody (AB117769)

Detection of ZNF292 by Western Blot of Immunprecipitate.
ab117769 at 1µg/ml staining ZNF292 in Jurkat whole cell lysate immunoprecipitated using ab117769 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
Detection : Chemiluminescence with exposure time of 30 seconds.

All lanes:

Immunoprecipitation - Anti-ZNF292 antibody (ab117769)

Predicted band size: 305 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP

applications

Immunogen

Synthetic Peptide within Human ZNF292 aa 2000-2050. The exact immunogen used to generate this antibody is proprietary information.

O60281

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab117769 was affinity purified using an epitope specific to ZNF292 immobilized on solid support.
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF292 also known as Zinc Finger Protein 292 is a zinc finger protein involved in transcriptional regulation. It has a molecular mass of approximately 300 kDa. This protein regulates gene expression by binding to DNA sequences. Generally you find ZNF292 expressed in various tissues with significant levels in the brain and liver. Its complex structure allows it to interact with diverse DNA motifs enabling versatile roles in cellular processes.
Biological function summary

The function of ZNF292 involves modulation of cell growth and differentiation. This protein interacts with other transcription factors and coregulatory molecules to influence gene expression patterns. Although not strictly part of a specific protein complex some reports suggest its involvement with general transcription machinery. ZNF292 plays an important role in development and normal cellular functions by modulating critical genes involved in growth pathways.

Pathways

ZNF292 engages in essential signaling cascades. It is notably linked to the Wnt and MAPK pathways. In the Wnt pathway ZNF292 acts alongside proteins like β-catenin to regulate the transcription of target genes involved in cellular proliferation. Within the MAPK pathway its interactions influence cell cycle regulation and response to external stimuli impacting proteins like MEK and ERK pivotal in transducing extracellular signals.

Certain aberrations in ZNF292 function associate with cancer and neurological disorders. In several types of cancer altered expression or mutations of ZNF292 disrupt normal transcriptional control contributing to tumorigenesis. Additionally ZNF292 shows connections to neurodevelopmental disorders potentially through disrupted interactions with proteins such as DYRK1A well-known for their roles in brain development. These associations highlight ZNF292 as a relevant target for therapeutic exploration in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in transcriptional regulation.
See full target information ZNF292
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer management and research 11:9585-9597 PubMed31814760

2019

Knockdown Of CCDC132 Attenuates Gastric Cancer Cells Proliferation And Tumorigenesis By Facilitating DNA Damage Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaowu Xu,Weilang Cao,Wei Sun,Zhaohong Wang,Hui Chen,Zhiqiang Zheng,Xiaomin Yang
View all publications
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Product promise

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