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AB67886

Anti-ZNF331 antibody

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(1 Publication)

Mouse Polyclonal ZNF331 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ZNF331.

View Alternative Names

RITA, ZNF361, ZNF463, ZNF331, Zinc finger protein 331, C2H2-like zinc finger protein rearranged in thyroid adenomas, Zinc finger protein 361, Zinc finger protein 463

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-ZNF331 antibody (AB67886)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ZNF331 antibody (AB67886)

ab67886 at 10μg/ml staining ZNF331 in Hela cells.

Western blot - Anti-ZNF331 antibody (AB67886)
  • WB

Unknown

Western blot - Anti-ZNF331 antibody (AB67886)

All lanes:

Western blot - Anti-ZNF331 antibody (ab67886) at 1/500 dilution

Lane 1:

ZNF331 transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 54 kDa

Observed band size: 44 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ZNF331.

Q9NQX6

Specificity

This antibody is reactive against mammalian transfected lysate.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p>NOTE: Product requires purification with Protein A prior to use in ICC/IF.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF331 also known as Zinc Finger Protein 331 is a member of the zinc finger protein family and functions as a transcriptional regulator. The protein weighs approximately 63 kDa. It carries zinc finger motifs that enable DNA binding which affects gene expression. ZNF331 frequently occurs in various tissues with higher expression levels in the spleen and lymph nodes. This suggests its role in the immune system or related physiological processes.
Biological function summary

ZNF331 acts as a transcriptional repressor influencing the regulation of target genes by binding to specific DNA sequences. It participates in regulating cell growth and apoptosis processes critical for maintaining cellular homeostasis. ZNF331 interacts with other proteins to form complexes that modulate chromatin structure affecting gene accessibility and transcription. The protein's expression pattern and molecular function indicate its involvement in tissue-specific regulatory mechanisms.

Pathways

Research shows ZNF331 participates in pathways related to cell cycle regulation and apoptotic signaling. It interacts with p53 signaling pathway components an important pathway involved in tumor suppression by triggering cell cycle arrest or apoptosis in response to DNA damage. ZNF331's interaction with such pathways implies its potential role in maintaining cellular integrity. Its related proteins such as p21 and cyclins further emphasize its function in cell cycle modulation.

Research links ZNF331 to various cancers particularly gastric and colorectal cancers. Abnormal expression patterns such as downregulation associate with tumor progression and malignancy. Additionally ZNF331 shows potential involvement in immune-mediated disorders due to its expression in lymphoid tissues. Disruption of its interaction with p53 and related proteins can exacerbate disease symptoms by permitting unchecked cellular proliferation highlighting its importance in oncogenesis and immune function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in transcriptional regulation. May play a role in spermatogenesis.
See full target information ZNF331
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncogene 32:307-17 PubMed22370639

2012

Zinc-finger protein 331, a novel putative tumor suppressor, suppresses growth and invasiveness of gastric cancer.

Applications

IHC-P, WB

Species

Human, Human

J Yu,Q Y Liang,J Wang,Y Cheng,S Wang,T C W Poon,M Y Y Go,Q Tao,Z Chang,J J Y Sung
View all publications
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Product promise

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