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AB272679

Anti-ZNF341 antibody

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Rabbit Polyclonal ZNF341 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF341 aa 350-450.

View Alternative Names

Zinc finger protein 341, ZNF341

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-ZNF341 antibody (AB272679)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ZNF341 antibody (AB272679)

PFA fixed, Triton X-100 permeablized A549 cells (Human lung carcinoma cell line) labeling ZNF341 (green) using ab272679 2t 4 ug/ml in ICC/IF analysis.

Western blot - Anti-ZNF341 antibody (AB272679)
  • WB

Unknown

Western blot - Anti-ZNF341 antibody (AB272679)

All lanes:

Western blot - Anti-ZNF341 antibody (ab272679) at 0.4 µg/mL

Lane 1:

RT4 cells (Human urinary bladder cancer cell line)

Lane 2:

U-251 MG cells (Human brain glioma cell line)

Predicted band size: 92 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human ZNF341 aa 350-450. The exact immunogen used to generate this antibody is proprietary information.

Q9BYN7

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF341 also known as zinc finger protein 341 is a transcription factor characterized by its zinc finger motifs which are essential for binding to DNA. It has an approximate molecular mass of 98 kDa. Researchers have observed ZNF341 expression primarily in lymphoid tissues suggesting a role in immune function. The protein engages directly with DNA to regulate gene expression impacting transcriptional activity which influences various cellular processes.
Biological function summary

The function of ZNF341 involves regulating the immune system. This protein influences the transcriptional regulation of genes linked to immune responses and development. ZNF341 does not typically form part of a larger protein complex instead acting independently to facilitate transcriptional activation or repression in immune cells. Its activity impacts the production of cytokines and antibodies which are important for mounting effective immune responses.

Pathways

ZNF341 plays significant roles in the immune response pathways such as the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway and the NF-kB signaling pathway. The JAK-STAT pathway involves various proteins including STAT3 and STAT5 which interact with ZNF341 to mediate gene expression involved in cell proliferation and defense mechanisms. ZNF341 also engages components of the NF-kB pathway to regulate inflammatory responses highlighting its importance in immune function.

ZNF341 is closely related to immunodeficiencies and autoimmune diseases. Hypomorphic mutations in ZNF341 can lead to a combined immunodeficiency characterized by a weakened immune system's inability to respond effectively to infections. The protein connects to the pathogenesis of these diseases through its interaction with other immune-related proteins like STAT3. Furthermore ZNF341's involvement in the regulation of immune responses can link it to autoimmune diseases where the overactive or misguided immune response targets the body's own tissues.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Transcriptional activator of STAT3 involved in the regulation of immune homeostasis. Also able to activate STAT1 transcription.
See full target information ZNF341

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