Anti-ZNF365 antibody [EPR10216] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The zinc finger protein 365 (ZNF365) also known as ZBRK1 is a transcription factor weighing approximately 107 kDa. This protein plays a mechanical role by binding to specific DNA sequences regulating the transcription of target genes. ZNF365 is expressed in various tissues including the brain heart and skeletal muscle. Its expression pattern suggests it may have versatile functions in different physiological contexts.

Biological function summary

ZNF365 acts as a critical regulatory component in maintaining genomic stability. It associates with the BRCA1 complex which is essential for repairing DNA double-strand breaks. By interacting with this complex ZNF365 participates in controlling cell cycle checkpoints ensuring accurate DNA replication and division. This process helps to prevent the accumulation of genomic abnormalities which could lead to diseases.

Pathways

This protein influences the DNA damage response and cell cycle regulation pathways. ZNF365 works in conjunction with protein partners like BRCA1 and RAD50 facilitating efficient repair of damaged DNA. Its involvement in these pathways ensures cells can respond to genetic insults timely and effectively safeguarding genetic information and controlling cellular proliferation rates.

Associated diseases and disorders

ZNF365 has a notable connection with cancer risk particularly breast cancer. Alterations in its function or expression can disrupt genome stability contributing to tumor genesis and progression. ZNF365 also interacts with p53 a tumor suppressor protein. Defects in these interactions may further compromise DNA repair processes highlighting its significance in cancer biology.