Anti-ZNF384 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ZNF384 also known as zinc finger protein 384 acts as a transcription factor. It has a molecular mass of approximately 55 kDa. This protein contains multiple zinc finger motifs allowing it to bind to DNA. ZNF384 regulates the expression of various genes linked to cellular processes. It localizes to the nucleus where it performs its function. Although broadly expressed the protein shows higher expression in tissues such as the brain and bone marrow.

Biological function summary

This transcription factor plays a role in controlling gene expression networks essential to differentiation and development. ZNF384 contributes significantly to the regulation of genes involved in cell growth and proliferation. It is known to interact with the transcriptional complexes influencing downstream gene expression events that contribute to developmental processes. ZNF384's functionality is important in maintaining the balance of cellular proliferation and differentiation.

Pathways

ZNF384 finds integration within the MAPK signaling pathway and the Wnt signaling pathway. These pathways respond to extracellular signals and control various cellular processes like growth and differentiation. ZNF384 interacts with proteins such as CBP and p300 which are coactivators that modulate transcriptional activities. These interactions help integrate signals from different pathways influencing specific cellular responses.

Associated diseases and disorders

Researchers associate ZNF384 with leukemia and osteosarcoma. In particular its fusion with transcriptional co-activators like EWS has implications in leukemogenesis often found in mixed-lineage leukemia (MLL). The presence of ZNF384 abnormalities may influence disease progression and patient prognosis. Understanding how ZNF384 interplays with related factors such as TET1 could provide insights into the pathogenesis of these disorders.