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AB222803

Anti-ZNF408 antibody

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(1 Publication)

Rabbit Polyclonal ZNF408 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF408 aa 300-650.

View Alternative Names

PFM14, PRDM17, ZNF408, Zinc finger protein 408, PR domain zinc finger protein 17

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF408 antibody (AB222803)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF408 antibody (AB222803)

Paraffin-embedded human testis tissue stained for ZNF408 using ab222803 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ZNF408 aa 300-650. The exact immunogen used to generate this antibody is proprietary information.

Q9H9D4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF408 also known as Zinc Finger Protein 408 is a protein with a mass of approximately 95 kDa. It belongs to the family of zinc finger proteins which play essential roles in DNA binding and transcription regulation. ZNF408 locates primarily in the nucleus of cells where it binds specific DNA sequences to influence the transcriptional activity. It expresses in various tissues with notable levels detected in the brain and heart suggesting a role in the functioning of these organs.
Biological function summary

This protein participates in the regulation of gene expression important for maintaining cellular homeostasis and function. ZNF408 is known to interact with DNA and potentially with other transcription factors forming a complex that modulates transcription. Through its zinc finger domains ZNF408 recognizes particular gene promoters influencing the transcription of genes related to cellular growth and development processes.

Pathways

Four pertinent biological interactions involve ZNF408's influence on the Wnt signaling pathway and possibly the Hedgehog signaling pathway. These pathways are important for proper embryonic development and maintaining adult tissue homeostasis. In these cascades ZNF408 interacts with other transcriptional regulators such as β-catenin in the Wnt pathway highlighting its role in modulating transcription in response to cellular signals.

ZNF408's function links to retinal diseases and certain cancers. Mutations or dysregulations in this protein may contribute to retinal degeneration potentially through its interaction with proteins like RPGRIP1. Additionally aberrant activity or expression of ZNF408 associates with cancer progression showing interactions with tumor suppressor proteins or oncogenes. Understanding ZNF408's detailed role may aid in designing targeted therapies for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in transcriptional regulation.
See full target information ZNF408
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 8:582220 PubMed33163494

2020

Protein Tyrosine Phosphatase Receptor S Acts as a Metastatic Suppressor in Malignant Peripheral Nerve Sheath Tumor via Profilin 1-Induced Epithelial-Mesenchymal Transition.

Applications

Unspecified application

Species

Unspecified reactive species

Jie-Yi Ren,Yi-Hui Gu,Xi-Wei Cui,Man-Mei Long,Wei Wang,Cheng-Jiang Wei,Bin Gu,Hai-Bing Zhang,Qing-Feng Li,Zhi-Chao Wang
View all publications
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Product promise

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