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AB216970

Anti-ZNF423 antibody

5

(1 Review)

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(1 Publication)

Rabbit Polyclonal ZNF423 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZNF423 aa 850-950 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

KIAA0760, NPHP14, OAZ, ZNF423, Zinc finger protein 423, Olf1/EBF-associated zinc finger protein, Smad- and Olf-interacting zinc finger protein, hOAZ

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF423 antibody (AB216970)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF423 antibody (AB216970)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat brain tissue labeling ZNF423 using ab216970 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human ZNF423 aa 850-950 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q2M1K9

Specificity

ab216970 may also detect the protein Midasin if used in Human.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF423 also known as OAZ or EBF-associated zinc finger protein acts mechanically as a transcription factor that interacts with DNA to regulate gene expression. This protein comprises of multiple zinc finger motifs enabling it to bind specifically to DNA sequences. ZNF423 has a mass of approximately 150 kDa. It is expressed in various tissues including brain and kidney where it plays a vital role in development and functioning of these organs.
Biological function summary

ZNF423 functions as an essential modulator of neurodevelopmental processes. It is a component of the nuclear receptor coactivator complex where it interacts with several other transcription factors to influence neuronal differentiation and proliferation. It exerts its biological function by regulating target genes involved in growth and development. This modulation activity makes ZNF423 important for proper embryonic development.

Pathways

Proteins within the DNA repair and neurotrophin signaling pathways engage with the actions of ZNF423. In the DNA repair pathway ZNF423 interacts with PARP-1 a critical protein in repairing DNA single-strand breaks to maintain genomic integrity. In the neurotrophin signaling pathway it works with proteins such as EBF1 to influence neuronal growth and survival highlighting its role in brain development and function.

Malfunctions in ZNF423 are associated with certain neurodevelopmental disorders and cancers. Nonsense mutations in the ZNF423 gene can lead to nephronophthisis a kidney disorder characterized by inflammation and scarring. Additionally abnormalities in ZNF423 expression often correlate with pediatric high-grade gliomas a form of aggressive brain tumors. In these contexts ZNF423 connects with proteins like SMAD4 impacting tumorigenesis and disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.
See full target information ZNF423
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 10:20678 PubMed33244099

2020

Differences in gynecologic tumor development in Amhr2-Cre mice with KRAS or KRAS mutations.

Applications

Unspecified application

Species

Unspecified reactive species

Eucharist H S Kun,Yvonne T M Tsang,Sophia Lin,Sophia Pan,Tejas Medapalli,Anais Malpica,JoAnne S Richards,David M Gershenson,Kwong-Kwok Wong
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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