Rabbit Polyclonal ZNF45 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF45.
View Alternative Names
KOX5, ZNF13, ZNF45, Zinc finger protein 45, BRC1744, Zinc finger protein 13, Zinc finger protein KOX5
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF45 antibody (AB228574)
Paraffin-embedded human colon carcinoma tissue stained for ZNF45 with ab228574 at 1/250 dilution in immunohistochemical analysis.
- ICC/IF
Supplier Data
Immunocytochemistry/ Immunofluorescence - Anti-ZNF45 antibody (AB228574)
A375 (human malignant melanoma cell line) cells stained for ZNF45 (green) using ab228574 (1/500 dilution) in ICC/IF. Cells were fixed in 4% paraformaldehyde at RT for 15 minutes. Counterstain : Hoechst 33342 (blue).
- ICC/IF
Supplier Data
Immunocytochemistry/ Immunofluorescence - Anti-ZNF45 antibody (AB228574)
HCT 166 (human colorectal carcinoma cell line) cells stained for ZNF45 (green) using ab228574 (1/500 dilution) in ICC/IF. Cells were fixed in 4% paraformaldehyde at RT for 15 minutes. Counterstain : Hoechst 33342 (blue).
- WB
Supplier Data
Western blot - Anti-ZNF45 antibody (AB228574)
7.5% SDS-PAGE
All lanes:
Western blot - Anti-ZNF45 antibody (ab228574) at 1/2000 dilution
All lanes:
HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 30 µg
Predicted band size: 78 kDa
true
Reactivity data
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Supplementary information
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Biological function summary
Zinc Finger Protein 45 regulates the expression of genes involved in cell growth and apoptosis. ZNF45 forms part of a larger protein complex which includes other zinc finger proteins and co-factors that modulate its activity. These interactions enable ZNF45 to control various cell processes such as proliferation and differentiation. Through its role in transcription regulation ZNF45 affects the overall cellular homeostasis which helps in maintaining normal cellular functions and responses to environmental signals.
Pathways
The Zinc Finger Protein 45 influences the p53 signaling pathway which plays a critical role in cell cycle regulation and apoptosis. As a transcriptional regulator ZNF45 interacts with other proteins such as MDM2 to modulate the activity of the p53 pathway. Additionally ZNF45 is part of the Wnt signaling pathway where it associates with proteins like β-catenin to regulate the expression of target genes involved in cell cycle progression and oncogenesis. These pathways are essential for maintaining cellular integrity and preventing uncontrolled cell growth.
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Publications (1)
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Thoracic cancer 16:e15485 PubMed39552193
2024
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Unspecified reactive species
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