JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB88862

Anti-ZNF468 antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Mouse Polyclonal ZNF468 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ZNF468.

View Alternative Names

Zinc finger protein 468, ZNF468

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-ZNF468 antibody (AB88862)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ZNF468 antibody (AB88862)

ab88862, at 10 μg/ml staining ZNF468 in HepG2 cells by Immunofluorescence.

Western blot - Anti-ZNF468 antibody (AB88862)
  • WB

Unknown

Western blot - Anti-ZNF468 antibody (AB88862)

All lanes:

Western blot - Anti-ZNF468 antibody (ab88862) at 1 µg/mL

All lanes:

Human pancreas tissue lysate at 50 µg

Predicted band size: 60 kDa

Observed band size: 49 kDa,54 kDa,70 kDa

false

Western blot - Anti-ZNF468 antibody (AB88862)
  • WB

Unknown

Western blot - Anti-ZNF468 antibody (AB88862)

All lanes:

Western blot - Anti-ZNF468 antibody (ab88862) at 1 µg/mL

Lane 1:

ZNF468 transfected 293T cell line lysate at 25 µg

Lane 2:

Non-transfected lysate at 25 µg

Predicted band size: 60 kDa

Observed band size: 48 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ZNF468.

Q5VIY5

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: 100% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF468 also known as Zinc Finger Protein 468 functions as a transcription factor. Its molecular mass is approximately 69 kDa. It contains multiple zinc finger motifs that bind to DNA regulating gene expression. This protein is expressed in nuclear compartments and detected in various tissues but shows high levels in brain and testis. This localization suggests that ZNF468 plays an essential role in processes involving DNA interaction and regulation.
Biological function summary

Transcription factors like ZNF468 influence cellular differentiation and development by activating or repressing specific genes. ZNF468 does not seem to be a part of a major protein complex but can cooperate with other transcription factors to modulate gene expression profiles. By directly binding to DNA sequences it executes its role in directing transcriptional regulation which can impact cellular growth and response mechanisms.

Pathways

Zinc finger proteins such as ZNF468 play critical roles in the regulation of the Wnt signaling pathway and the apoptosis pathway. Through its regulatory functions ZNF468 affects the expression of genes involved in these pathways. It influences cellular proliferation and survival processes working in a network with other proteins like beta-catenin and c-Myc which are recognized components of these pathways. This involvement highlights the importance of maintaining proper ZNF468 function for cellular equilibrium.

Aberrations in ZNF468 expression or function relate to issues in neuromuscular diseases and certain cancers where regulation of cell growth is disrupted. For example in oncogenesis its interaction with other transcription factors might influence the expression of oncogenes such as p53. Neuromuscular disorders may arise from its role in neuronal development and maintenance as imbalances in gene expression can lead to degeneration. Consequently any mutation or dysregulation of ZNF468 can potentially impact cellular pathways and lead to disease progression.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

May be involved in transcriptional regulation.
See full target information ZNF468
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular and molecular medicine 29:e70724 PubMed40702875

2025

ZNF468/AURKA/PI3K/AKT Positive Feedback Loop Promotes Proliferation and Metastasis of Oesophageal Squamous Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Ge Bai,Lei Wang,Li Zhang,Mayinur Eli

Cell death & disease 12:170 PubMed33568630

2021

Akt kinase LANCL2 functions as a key driver in EGFR-mutant lung adenocarcinoma tumorigenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Yuqing Lou,Jianlin Xu,Yanwei Zhang,Wei Zhang,Xueyan Zhang,Ping Gu,Hua Zhong,Huimin Wang,Jun Lu,Baohui Han
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB88613

Anti-PRUNE antibody

Immunocytochemistry/ Immunofluorescence - Anti-PRUNE antibody (AB88613)

  • 4
  • 2
Primary Antibodies

AB154864

Anti-UGT2B15 antibody [EPR10615(B)]

RabMAb|Recombinant

Western blot - Anti-UGT2B15 antibody [EPR10615(B)] (AB154864)

  • 0
  • 0
Primary Antibodies

AB300103

Anti-ULBP3 antibody [EPR22321-99] (BSA and Azide free)

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-ULBP3 antibody [EPR22321-99] (BSA and Azide free) (AB300103)

  • 0
  • 0
Primary Antibodies

AB96214

Anti-UGT1A9 antibody

Western blot - Anti-UGT1A9 antibody (AB96214)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com