Rabbit Polyclonal ZNF503 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF503 aa 100-300.
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- OncoTargets and therapy 13:6361-63712020LncRNA TTN-AS1 Promotes Progression of Non-Small Cell Lung Cancer via Regulating miR-491-5p/ZNF503 Axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGuanbin Qi et. al.PubMed 32669856
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human ZNF503 aa 100-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q96F45
Reactivity data
Select an application| IHC-P | WB | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
| Mouse | Predicted | Predicted | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/200.00000 - 1/500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.04000-0.40000 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes Fixation/Permeabilization: PFA/Triton X-100. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
Associated Products
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2 products for Alternative Product
Alternative names
Zinc finger protein 503, NOLZ1, ZNF503
Recommended products
Rabbit Polyclonal ZNF503 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF503 aa 100-300.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human ZNF503 aa 100-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q96F45
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ZNF503 also known as Zfp503 or Zeppo1 is a zinc finger protein with a molecular weight of approximately 55 kDa. ZNF503 consists of zinc finger domains which contribute to its function as a transcription factor. This protein is expressed in several tissues including the brain heart and lungs. ZNF503 interacts with DNA to either activate or repress transcription of specific genes controlling various cellular processes.
- Biological function summary
ZNF503 plays an important role in the regulation of development and differentiation processes. It often functions as part of a transcriptional regulatory complex. This protein modulates the transcriptional activity affecting gene expression profiles according to the cellular context. It is essential in early embryonic development and neuronal differentiation contributing to the proper formation and function of these tissues.
- Pathways
ZNF503 is a significant modulator of the Wnt signaling pathway which influences cell growth differentiation and migration. In the context of Wnt signaling ZNF503 interacts with other key proteins such as β-catenin facilitating Wnt pathway regulation. ZNF503 also associates with the Notch signaling pathway where it impacts cellular communication and fate decisions by interacting with components like Notch receptors and ligands.
- Associated diseases and disorders
ZNF503 has been implicated in cancer and neurodevelopmental disorders. Aberrant expression of ZNF503 is linked to tumorigenesis particularly in breast cancer where it interacts with proteins like HER2 to promote cancerous growth. In developmental disorders such as intellectual disabilities ZNF503 may influence neural development through its interactions with proteins involved in synaptic formation and maintenance leading to cognitive impairments when dysregulated.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
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6 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF503 antibody (ab254715)
Paraffin-embedded human endometrium tissue stained for ZNF503 using ab254715 at 1/200 dilution in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF503 antibody (ab254715)
Paraffin-embedded human rectum tissue stained for ZNF503 using ab254715 at 1/200 dilution in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF503 antibody (ab254715)
Paraffin-embedded human prostate tissue stained for ZNF503 using ab254715 at 1/200 dilution in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF503 antibody (ab254715)
Paraffin-embedded human tonsil tissue stained for ZNF503 using ab254715 at 1/200 dilution in immunohistochemical analysis. Low positivity in lymphoid cells.
Western blot - Anti-ZNF503 antibody (ab254715)
All lanes: Western blot - Anti-ZNF503 antibody (ab254715) at 0.4 µg/mL
Lane 1: PC-3 cell lysate
Lane 2: MCF7 cell lysate
Predicted band size: 63 kDa
Immunocytochemistry/ Immunofluorescence - Anti-ZNF503 antibody (ab254715)
PFA fixed, Triton X-100 permeabilized U-2 OS (Human bone osteosarcoma epithelial cell line) cells labeling ZNF503 using ab254715 at 4µg/ml (green) in ICC/IF.
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