Anti-ZNF503 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ZNF503 also known as Zfp503 or Zeppo1 is a zinc finger protein with a molecular weight of approximately 55 kDa. ZNF503 consists of zinc finger domains which contribute to its function as a transcription factor. This protein is expressed in several tissues including the brain heart and lungs. ZNF503 interacts with DNA to either activate or repress transcription of specific genes controlling various cellular processes.

Biological function summary

ZNF503 plays an important role in the regulation of development and differentiation processes. It often functions as part of a transcriptional regulatory complex. This protein modulates the transcriptional activity affecting gene expression profiles according to the cellular context. It is essential in early embryonic development and neuronal differentiation contributing to the proper formation and function of these tissues.

Pathways

ZNF503 is a significant modulator of the Wnt signaling pathway which influences cell growth differentiation and migration. In the context of Wnt signaling ZNF503 interacts with other key proteins such as β-catenin facilitating Wnt pathway regulation. ZNF503 also associates with the Notch signaling pathway where it impacts cellular communication and fate decisions by interacting with components like Notch receptors and ligands.

Associated diseases and disorders

ZNF503 has been implicated in cancer and neurodevelopmental disorders. Aberrant expression of ZNF503 is linked to tumorigenesis particularly in breast cancer where it interacts with proteins like HER2 to promote cancerous growth. In developmental disorders such as intellectual disabilities ZNF503 may influence neural development through its interactions with proteins involved in synaptic formation and maintenance leading to cognitive impairments when dysregulated.