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AB111697

Anti-ZNF587 antibody

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(3 Publications)

Rabbit Polyclonal ZNF587 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF587 aa 50-300.

View Alternative Names

Zinc finger protein 587, ZNF587

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF587 antibody (AB111697)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF587 antibody (AB111697)

ab111697 at 1/500 dilution staining ZNF587 in Formalin-fixed, paraffin-embedded SkHep1 xenograft tissue by Immunohistochemistry.

Western blot - Anti-ZNF587 antibody (AB111697)
  • WB

Unknown

Western blot - Anti-ZNF587 antibody (AB111697)

7.5% SDS-PAGE.

All lanes:

Western blot - Anti-ZNF587 antibody (ab111697) at 1/1000 dilution

All lanes:

Jurkat whole cell lysate at 30 µg

Predicted band size: 66 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ZNF587 aa 50-300. The exact immunogen used to generate this antibody is proprietary information.

Q96SQ5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF587 also known as Zinc Finger Protein 587 acts as a transcription factor that binds to DNA to regulate gene expression. This protein contains C2H2-type zinc finger motifs which help it attach to specific DNA sequences. Its exact molecular mass remains not well-documented but like many zinc finger proteins it exists within the range typical for such transcription factors. ZNF587 expression occurs mainly in tissues of the reproductive system with notable presence in testis and ovary which indicates its role related to reproductive biological processes.
Biological function summary

Zinc finger proteins like ZNF587 play a role in transcriptional regulation by modulating the activity of other genes. ZNF587 is not known to form part of a larger protein complex but it interacts with different transcriptional machinery components to influence gene expression patterns. Its ability to bind to specific DNA regions makes it an essential regulator in maintaining normal cellular functions and possibly developmental processes related to its expression profile in reproductive tissues.

Pathways

Zinc finger proteins such as ZNF587 contribute to the intricate network of gene expression regulation part-taking in pathways such as the Wnt signaling pathway. Within this pathway ZNF587 regulates genes that control cell growth movement and differentiation working alongside proteins like β-catenin which also influences transcription by binding to DNA. This interaction highlights ZNF587's role in key signaling networks that dictate important cellular decisions and developmental cues.

Research indicates connections between ZNF587 and certain reproductive system diseases including testicular cancer and polycystic ovary syndrome (PCOS). In testicular cancer altered expression of ZNF587 and its interactions with other zinc finger proteins may contribute to the pathogenesis. For PCOS ZNF587's role in reproductive tissue suggests a possible impact on the gene networks disrupted in this disorder potentially involving proteins like FSHR that regulate ovary function. Therefore understanding ZNF587 function can illuminate pathways that lead to reproductive health issues.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in transcriptional regulation.
See full target information ZNF587
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:7214 PubMed40764480

2025

The RING finger E3 ligase RNF25 protects DNA replication forks independently of its canonical roles in ubiquitin signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Lilly F Chiou,Gaith N Droby,Deepika Jayaprakash,Jay R Anand,Xingyuan Zhang,Yang Yang,C Allie Mills,Thomas S Webb,Natalie K Barker,Jialiu Xie,Di Wu,Laura E Herring,Junya Tomida,Jessica L Bowser,Cyrus Vaziri

The journal of gene medicine 24:e3453 PubMed36181243

2022

The long non-sacoding RNA TMEM147-AS1/miR-133b/ZNF587 axis regulates the Warburg effect and promotes prostatic carcinoma invasion and proliferation.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Wu,Niwei Han,Changyong Zhao,Xiang Huang,Peng Su,Xiaoguang Li

Bioengineered 12:8457-8467 PubMed34670480

2021

MiRNA-4537 functions as a tumor suppressor in gastric cancer and increases the radiosensitivity of gastric cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Liu,Sili Yan,Jun Hu,Dong Ding,Yang Liu,Xia Li,Hai Song Pan,Gengxin Liu,Bo Wu,Yu Liu
View all publications
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Product promise

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