Anti-ZNF592 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ZNF592 also known as Zinc Finger Protein 592 is a protein with a molecular mass of approximately 148 kDa. It performs its functions as a transcriptional regulator due to its zinc finger domains which facilitate DNA binding. Researchers have observed its expression across various tissues including the central nervous system where it likely has significant roles due to its regional specificity. By binding to specific DNA sequences ZNF592 regulates the transcription of associated genes influencing cellular processes and development.

Biological function summary

The protein affects neural development and function playing important roles in maintaining the stability of neuron processes. It becomes part of transcriptional regulatory complexes where it interfaces with other proteins to modulate gene expression related to neuronal differentiation. Its activity helps guide the appropriate formation and maintenance of neural networks which are essential for correct brain function. Studies suggest ZNF592 works in regulation with various neuronal transcription factors adding layers of control to the expression pattern of neural genes.

Pathways

ZNF592 has significant contributions to the neurogenesis and neural differentiation pathways where it modulates the expression of key regulatory genes. It operates in relation to pathways involving other important transcription factors like REST (repressor element 1-silencing transcription factor) and soforth ensures the maintenance of neural progenitor cell identity and lineage specification. ZNF592 interacts with these factors to balance cell proliferation and differentiation in the central nervous system.

Associated diseases and disorders

Mutations or dysregulation of ZNF592 link to neurological conditions such as intellectual disabilities and spinocerebellar ataxia. These conditions reflect the protein’s critical function in neural development and the delicate balance of neuronal cell regulatory mechanisms. In particular ZNF592 associates with the protein Ataxin-1 where they together may contribute to the development of spinocerebellar ataxia type 1 revealing potential pathogenic pathways involving faulty transcriptional regulation in neural tissues. Understanding these connections prompts further research into therapeutic strategies targeting these dysfunctions.