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AB240699

Anti-ZNF592 antibody

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(1 Publication)

Rabbit Polyclonal ZNF592 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZNF592 aa 200-250.

View Alternative Names

KIAA0211, ZNF592, Zinc finger protein 592

2 Images
Immunoprecipitation - Anti-ZNF592 antibody (AB240699)
  • IP

Supplier Data

Immunoprecipitation - Anti-ZNF592 antibody (AB240699)

ZNF592 was immunoprecipitated from HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate (1 mg for IP, 20% of IP loaded) using ab240699 at 3 μg/mL. Western blot was performed on the immunoprecipitate using ab240699 at 1 μg/mL.

Lane 1 : ab240699 IP in HeLa whole cell lysate.
Lane 2 : Control IgG (-).

Detection : Chemiluminescence with an exposure time of 3 seconds.

All lanes:

Immunoprecipitation - Anti-ZNF592 antibody (ab240699)

Predicted band size: 138 kDa

false

Western blot - Anti-ZNF592 antibody (AB240699)
  • WB

Supplier Data

Western blot - Anti-ZNF592 antibody (AB240699)

All lanes:

Western blot - Anti-ZNF592 antibody (ab240699) at 0.04 µg/mL

Lane 1:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg

Lane 2:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 15 µg

Lane 3:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 5 µg

Predicted band size: 138 kDa

true

Exposure time: 10s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IP

applications

Immunogen

Synthetic Peptide within Human ZNF592 aa 200-250. The exact immunogen used to generate this antibody is proprietary information.

Q92610

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-5 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF592 also known as Zinc Finger Protein 592 is a protein with a molecular mass of approximately 148 kDa. It performs its functions as a transcriptional regulator due to its zinc finger domains which facilitate DNA binding. Researchers have observed its expression across various tissues including the central nervous system where it likely has significant roles due to its regional specificity. By binding to specific DNA sequences ZNF592 regulates the transcription of associated genes influencing cellular processes and development.
Biological function summary

The protein affects neural development and function playing important roles in maintaining the stability of neuron processes. It becomes part of transcriptional regulatory complexes where it interfaces with other proteins to modulate gene expression related to neuronal differentiation. Its activity helps guide the appropriate formation and maintenance of neural networks which are essential for correct brain function. Studies suggest ZNF592 works in regulation with various neuronal transcription factors adding layers of control to the expression pattern of neural genes.

Pathways

ZNF592 has significant contributions to the neurogenesis and neural differentiation pathways where it modulates the expression of key regulatory genes. It operates in relation to pathways involving other important transcription factors like REST (repressor element 1-silencing transcription factor) and soforth ensures the maintenance of neural progenitor cell identity and lineage specification. ZNF592 interacts with these factors to balance cell proliferation and differentiation in the central nervous system.

Mutations or dysregulation of ZNF592 link to neurological conditions such as intellectual disabilities and spinocerebellar ataxia. These conditions reflect the protein’s critical function in neural development and the delicate balance of neuronal cell regulatory mechanisms. In particular ZNF592 associates with the protein Ataxin-1 where they together may contribute to the development of spinocerebellar ataxia type 1 revealing potential pathogenic pathways involving faulty transcriptional regulation in neural tissues. Understanding these connections prompts further research into therapeutic strategies targeting these dysfunctions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in transcriptional regulation.
See full target information ZNF592
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

HGG advances 6:100391 PubMed39663698

2024

Whole-exome sequencing reveals known and candidate genes for hearing impairment in Mali.

Applications

Unspecified application

Species

Unspecified reactive species

Abdoulaye Yalcouyé,Isabelle Schrauwen,Oumou Traoré,Salia Bamba,Elvis Twumasi Aboagye,Anushree Acharya,Thashi Bharadwaj,Rachel Latanich,Kevin Esoh,Cesar A Fortes-Lima,Carmen de Kock,Mario Jonas,Alassane Dit Baneye Maiga,Cheick A K Cissé,Moussa A Sangaré,Cheick O Guinto,Guida Landouré,Suzanne M Leal,Ambroise Wonkam
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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