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AB169079

Anti-ZNF593 antibody

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Mouse Polyclonal ZNF593 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF593 aa 1 to C-terminus.

View Alternative Names

ZT86, ZNF593, Zinc finger protein 593, Zinc finger protein T86

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-ZNF593 antibody (AB169079)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ZNF593 antibody (AB169079)

Immunofluorescent analysis of HeLa cells labeling ZNF593 with ab169079 at 10μg/ml.

Western blot - Anti-ZNF593 antibody (AB169079)
  • WB

Unknown

Western blot - Anti-ZNF593 antibody (AB169079)

All lanes:

Western blot - Anti-ZNF593 antibody (ab169079) at 1 µg/mL

Lane 1:

ZNF593-transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Predicted band size: 15 kDa

true

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ZNF593 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O00488

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF593 also known as Zinc Finger Protein 593 is a protein with a mass of approximately 30 kDa. It functions as a transcriptional regulator modulating gene expression through binding DNA. ZNF593 is expressed mainly in the nucleus of cells with a concentration in tissues such as the liver kidney and heart. Its zinc finger motif suggests a role in DNA binding and regulatory functions.
Biological function summary

ZNF593 is essential in managing the transcriptional activities within cells. It associates with a multiprotein complex interacting with other proteins to influence transcription. This protein plays a role in regulating cell proliferation and differentiation impacting how cells specialize and grow. Its involvement in interaction with RNA polymerase II highlights its role in gene expression regulation making it important in managing various cellular processes.

Pathways

This protein enhances our understanding of cellular signaling and communication. ZNF593 is involved in the MAPK/ERK and JAK/STAT signaling pathways. These pathways control essential processes like cell growth differentiation and response to external stimuli. ZNF593 interacts directly with key proteins within these pathways such as ERK and STAT which further supports its role in modulating cell fate decisions and signaling cascades.

ZNF593’s deregulation links to certain cancers and developmental disorders. Abnormal expression of ZNF593 correlates with progression in liver cancer where it impacts cell proliferation and survival. In addition mutations affecting ZNF593 have been associated with intellectual disabilities. Its interaction with proteins like STAT in these contexts underlines its pathological significance emphasizing the importance of proper regulation for maintaining cellular health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome (PubMed : 32669547). Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity (PubMed : 9115366).
See full target information ZNF593
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Product promise

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