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AB272674

Anti-ZNF618 antibody

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Rabbit Polyclonal ZNF618 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF618 aa 200-300.

View Alternative Names

KIAA1952, ZNF618, Zinc finger protein 618

2 Images
Western blot - Anti-ZNF618 antibody (AB272674)
  • WB

Unknown

Western blot - Anti-ZNF618 antibody (AB272674)

All lanes:

Western blot - Anti-ZNF618 antibody (ab272674) at 0.4 µg/mL

All lanes:

RT4 cells (Human urinary bladder cancer cell line)

Predicted band size: 104 kDa

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Immunocytochemistry/ Immunofluorescence - Anti-ZNF618 antibody (AB272674)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ZNF618 antibody (AB272674)

PFA fixed, Triton X-100 permeablized A549 cells (human lung carcinoma cell line) labeling ZNF618 (green) using ab272674 at 2 ug/ml in ICC/IF analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human ZNF618 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.

Q5T7W0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04000-0.40000 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25000-2.00000 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF618 also known as Zinc Finger Protein 618 acts as a nuclear protein involved in transcriptional regulation. The molecular weight of ZNF618 is approximately 104 kDa. It localizes mainly in the nucleus where it binds DNA to modulate gene expression. This protein exhibits high expression in tissues like the brain and liver suggesting specific regulatory roles in these organs.
Biological function summary

ZNF618 participates in regulating various genes making it essential for cellular processes. While ZNF618 does not function as part of a larger protein complex it interacts with other transcription factors coordinating gene expression patterns necessary for cell growth and differentiation. Its activity influences the transcription of genes responsible for developmental processes and cellular response to external stimuli.

Pathways

ZNF618 plays a role in pathways related to gene expression regulation and signal transduction. It specifically interacts within the MAPK signaling pathway connecting with proteins like ERK1/2 which are important for cellular proliferation and survival. The influence of ZNF618 in this pathway links it to transcriptional responses triggered by extracellular cues affecting cellular adaptation and function.

Researchers have identified links between ZNF618 dysregulation and neurological conditions such as autism spectrum disorder and schizophrenia. Altered ZNF618 expression impacts the balance of transcriptional networks necessary for normal brain function. Its interaction with proteins like MECP2 known for its association with neurodevelopmental disorders highlights its importance in maintaining neural homeostasis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulates UHRF2 function as a specific 5-hydroxymethylcytosine (5hmC) reader by regulating its chromatin localization.
See full target information ZNF618
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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