AB204595

Anti-ZNF692 antibody

Name: Anti-ZNF692 antibody (ab204595) | Abcam
Brand: Abcam Limited
SKU: AB204595

Be the first to review this product! Submit a review

(4 Publications)

Rabbit Polyclonal ZNF692 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF692 aa 100-200.

View Alternative Names

AREBP, ZFP692, ZNF692, Zinc finger protein 692, AICAR responsive element binding protein

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-ZNF692 antibody (AB204595)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ZNF692 antibody (AB204595)

Immunofluorescent analysis of HeLa cells (PFA-fixed/Triton X-100 permeabilized) labeling ZNF692 with ab204595 at 4μg/ml (green).

Supplier Data

Western blot - Anti-ZNF692 antibody (AB204595)

All lanes:

Western blot - Anti-ZNF692 antibody (ab204595) at 1/100 dilution

Lane 1:

RT-4 cell lysate

Lane 2:

U-251 MG lysate

Lane 3:

Human plasma lysate

Lane 4:

Human liver lysate

Predicted band size: 57 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ZNF692 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q9BU19

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF692 also known as Zinc Finger Protein 692 functions mechanically as a transcription factor involved in gene expression. This protein weighing approximately 70 kDa contains zinc finger motifs that facilitate its binding to DNA sequences. ZNF692 is expressed in various tissues with significant expression in the liver and kidney. Its role in binding DNA suggests that it might influence the transcription of specific genes by regulating their expression.

Biological function summary

ZNF692 interacts with other nuclear proteins to perform its functions effectively. It acts as part of a complex that regulates transcriptional networks influencing cellular responses and development. This zinc finger protein plays an essential role in cellular differentiation processes and might be critical in the maintenance of cellular identity. ZNF692's interaction with other proteins can modulate its activity within the cell nucleus affecting the transcriptional regulation of genes involved in cell growth and division.

Pathways

ZNF692 integrates into several key biological networks influencing gene expression. It associates with pathways such as the Wnt signaling pathway which is vital for cell proliferation differentiation and apoptosis. ZNF692's function within the Wnt pathway may involve interactions with β-catenin a central protein in this signaling cascade. Another pathway where ZNF692 might have a role is the MAPK pathway where it could modulate signal transduction processes that affect cellular responses to external stimuli.

Aberrant expression or mutations of ZNF692 have potential links to liver disease and certain types of cancers. In liver disease altered ZNF692 activity might disrupt normal liver function and gene expression. In cancer ZNF692 could be associated with genes controlling cell division and survival possibly influencing tumor progression. The dysregulation of proteins like β-catenin in these diseases suggests that ZNF692's interactions in these pathways could be therapeutically relevant for understanding and targeting these conditions.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway.

See full target information ZNF692

style

left-column

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Biology direct 19:28 PubMed38650011

2024

ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Di Zheng,Zhun Wei,Chong Zhang,Wenda Liu,Changtian Gong,Fei Wu,Weichun Guo

Cell reports 42:113280 PubMed37851577

2023

ZNF692 organizes a hub specialized in 40S ribosomal subunit maturation enhancing translation in rapidly proliferating cells.

Applications

Unspecified application

Species

Unspecified reactive species

M Carmen Lafita-Navarro,Yi-Heng Hao,Chunhui Jiang,Seoyeon Jang,Tsung-Cheng Chang,Isabella N Brown,Niranjan Venkateswaran,Elizabeth Maurais,Weronika Stachera,Yanfeng Zhang,Dorothy Mundy,Jungsoo Han,Vanna M Tran,Marcel Mettlen,Lin Xu,Jeffrey B Woodruff,Nick V Grishin,Lisa Kinch,Joshua T Mendell,Michael Buszczak,Maralice Conacci-Sorrell

Gynecologic oncology 152:396-407 PubMed30466806

2018

A clinical, biologic and mechanistic analysis of the role of ZNF692 in cervical cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Biqing Zhu,Yinpeng Pan,Xiufen Zheng,Quanli Zhang,Yaqin Wu,Jing Luo,Qian Li,Emei Lu,Lin Xu,Guangfu Jin,Binhui Ren

Science (New York, N.Y.) 362: PubMed30385546

2018

Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.

Applications

Unspecified application

Species

Unspecified reactive species

Quinlan L Sievers,Georg Petzold,Richard D Bunker,Aline Renneville,Mikołaj Słabicki,Brian J Liddicoat,Wassim Abdulrahman,Tarjei Mikkelsen,Benjamin L Ebert,Nicolas H Thomä

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ZNF692 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZNF692 antibody (AB204595)

Western blot - Anti-ZNF692 antibody (AB204595)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Product promise