Anti-ZNF703 antibody [EPR9050] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ZNF703 also known as Zinc Finger Protein 703 weighs about 62 kDa. This protein functions as a transcription factor playing a significant role in the regulation of gene expression. It mainly localizes to the nucleus where it binds to specific DNA sequences to exert its effects. Reports indicate ZNF703 expression in various tissues such as embryonic stem cells and different cancer types suggesting its importance in development and disease states.

Biological function summary

The involvement of ZNF703 in transcription regulation is critical for cellular processes. Acting as part of the transcriptional repressor complexes ZNF703 interacts with other proteins such as CtBP1 and CtBP2. This interaction results in modulation of the expression of genes that are important for cell cycle progression and developmental pathways. Research highlights its regulatory function in balancing cell proliferation and differentiation impacting both normal and pathological conditions.

Pathways

ZNF703 interacts with several important signaling networks including the E2F and Wnt pathways. Through these interactions ZNF703 influences cell cycle regulation and proliferation. Within these pathways ZNF703 interacts with proteins such as E2F transcription factors and β-catenin which play roles in cell cycle control and developmental processes. These connections illustrate how ZNF703 integrates into a larger cellular network to sustain proper cellular function.

Associated diseases and disorders

Researchers associate ZNF703 with breast cancer and glioblastoma. Amplification and overexpression of ZNF703 in breast cancer correlate with aggressive tumor phenotypes highlighting its role as an oncogene. ZNF703 also interacts with other cancer-related proteins like MYC enhancing its role in driving tumor progression. Moreover studies indicate ZNF703 overexpression in glioblastoma where it contributes to uncontrolled cell proliferation providing insights into its potential as a therapeutic target.