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AB121804

Anti-ZNF704 antibody

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(2 Publications)

Rabbit Polyclonal ZNF704 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF704 aa 300-400.

View Alternative Names

Zinc finger protein 704, ZNF704

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-ZNF704 antibody (AB121804)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ZNF704 antibody (AB121804)

Immunofluorescent staining of Human cell line A-431 shows positivity in nucleus but not nucleoli. Recommended concentration of ab121804 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Western blot - Anti-ZNF704 antibody (AB121804)
  • WB

Supplier Data

Western blot - Anti-ZNF704 antibody (AB121804)

All lanes:

Western blot - Anti-ZNF704 antibody (ab121804) at 0.04 µg/mL

Predicted band size: 45 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ZNF704 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.

Q6ZNC4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "<p>Recommend PFA Fixation and Triton X-100 treatment</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF704 also known as Zinc Finger Protein 704 is a transcription factor that influences gene expression. It contains zinc finger domains enabling it to bind DNA and regulate transcription. The protein exhibits a mass of approximately 43 kDa. Expression of ZNF704 occurs in various tissues but it is more prominent in the brain and reproductive organs. This spatial distribution suggests a role in neural and reproductive functions.
Biological function summary

The functions of ZNF704 link tightly to transcriptional regulation and cellular proliferation. It commonly functions as part of a chromatin-remodeling complex modifying the structure of chromatin to either promote or inhibit gene transcription. ZNF704 interactions often compromise critical control of the cell cycle and affect genes responsible for cell division and differentiation. Through these interactions ZNF704 has an impact on development and physiological processes.

Pathways

The activity of ZNF704 influences key signaling pathways including the Wnt and Notch pathways. Both pathways are central to processes like embryogenesis and cell fate determination. ZNF704 also exhibits interactions with proteins such as β-catenin in the Wnt pathway and NICD in the Notch pathway. These interactions suggest that ZNF704 plays a role in modulating the transcriptional outputs of these signaling cascades. Through this modulation ZNF704 can affect cellular functions and developmental processes.

Research connects ZNF704 to certain cancers and neurodevelopmental disorders. In cancer ZNF704 overexpression links to breast and ovarian cancers. ZNF704 interacts with proteins like p53 which is important for tumor suppression suggesting a potential role in tumor progression when dysregulated. Additionally alterations in ZNF704 expression correlate with neurodevelopmental disorders potentially due to its role in brain development and its interaction with neurodevelopmental proteins. These associations highlight the importance of understanding ZNF704 for insights into these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer.
See full target information ZNF704
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Oncology 102:354-365 PubMed37812924

2023

Kinesin Family Member B18 Is Related to Gastric Mucin Phenotype and Contributes to Gastric Cancer Progression by Regulating Epithelial-Mesenchymal Transition.

Applications

Unspecified application

Species

Unspecified reactive species

Akira Ishikawa,Ryo Yasumatsu,Takafumi Fukui,Aya Kido,Narutaka Katsuya,Kazuhiro Sentani,Kazuya Kuraoka,Naohide Oue,Takahisa Suzuki,Shiro Oka,Takahiro Kotachi,Kazuaki Tanabe,Hideki Ohdan,Hassan Ashktorab,Duane Smoot,Wataru Yasui

Cancer management and research 13:4911-4919 PubMed34188544

2021

Identification of ZNF704 as a Novel Oncogene and an Independent Prognostic Marker in Chondrosarcoma.

Applications

Unspecified application

Species

Unspecified reactive species

Changbao Chen,Hua Zhou,Xiaolin Zhang,Zhongjun Liu,Xinlong Ma
View all publications
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Product promise

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