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AB254776

Anti-ZNF711 antibody

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(3 Publications)

Rabbit Polyclonal ZNF711 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF711 aa 50-200.

View Alternative Names

CMPX1, ZNF6, ZNF711, Zinc finger protein 711, Zinc finger protein 6

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF711 antibody (AB254776)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF711 antibody (AB254776)

Paraffin-embedded human cerebellum tissue stained for ZNF711 using ab254776 at 1/500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF711 antibody (AB254776)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF711 antibody (AB254776)

Paraffin-embedded human liver tissue stained for ZNF711 using ab254776 at 1/500 dilution in immunohistochemical analysis. Low expression as expected.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF711 antibody (AB254776)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF711 antibody (AB254776)

Paraffin-embedded human cerebral cortex tissue stained for ZNF711 using ab254776 at 1/500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF711 antibody (AB254776)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF711 antibody (AB254776)

Paraffin-embedded human testis tissue stained for ZNF711 using ab254776 at 1/500 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ZNF711 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

Q9Y462

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZNF711 also known as Zinc Finger Protein 711 plays a role in transcriptional regulation. This protein contains multiple zinc-finger domains which allow it to bind to specific DNA sequences influencing gene expression by either activating or repressing transcription. ZNF711 has a molecular mass of roughly 92 kDa and is primarily expressed in the brain where it likely influences neural development and function.
Biological function summary

Zinc Finger Protein 711 functions within the DNA-binding transcription factor family. It interacts with other transcription regulators to modulate the expression of genes critical for brain development and function. ZNF711 does not usually act alone but as part of larger protein complexes which offer it the ability to exert broader gene regulatory functions. Being part of complexes enhances its role in fine-tuning gene expression patterns.

Pathways

ZNF711 is involved in the transcriptional regulation pathways including the retinoic acid signaling pathway. The protein interacts with other transcription factors such as those in the nuclear hormone receptor family. It may also influence pathways related to neural differentiation and synaptic transmission. Through these pathways ZNF711 orchestrates various stages of neural development and affects growth and functioning of neurons.

Mutations or dysregulation of ZNF711 links to X-linked intellectual disability which could affect synaptic signaling and neuronal communication. These mutations result in altered expression levels of key developmentally regulated genes. Additionally it may interact with proteins related to autism spectrum disorders like FMR1 which plays a role in synaptic plasticity. Disturbances in ZNF711 associated pathways can contribute to neurological impairments.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription regulator required for brain development (PubMed : 20346720). Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activated expression of genes involved in neuron development, such as KDM5C (PubMed : 20346720, PubMed : 31691806). May compete with transcription factor ARX for activation of expression of KDM5C (PubMed : 31691806).
See full target information ZNF711
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Clinics (Sao Paulo, Brazil) 78:100129 PubMed36473368

2022

Mesenchymal stem cells-derived exosomal miR-653-5p suppresses laryngeal papilloma progression by inhibiting BZW2.

Applications

Unspecified application

Species

Unspecified reactive species

Binya Hu,Min Huang,Lihua Tao,Yun Li,Yuting Kuang,Guangliang Liu,Sijun Zhao

EBioMedicine 71:103558 PubMed34521054

2021

ZNF711 down-regulation promotes CISPLATIN resistance in epithelial ovarian cancer via interacting with JHDM2A and suppressing SLC31A1 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Geyan Wu,Hu Peng,Miaoling Tang,Meisongzhu Yang,Jun Wang,Yameng Hu,Ziwen Li,Jun Li,Zheng Li,Libing Song

OncoTargets and therapy 13:6593-6601 PubMed32753895

2020

Clinical Significance of ZNF711 in Human Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyan Li,Liu Tian,Lina Zhang,Baojin Xu,Yong Zhang,Qiang Li
View all publications
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Product promise

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