Anti-ZNF774 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ZNF774 also known as Zinc Finger Protein 774 is a transcription factor characterized by the presence of C2H2-type zinc finger motifs. It has an approximate mass of 47 kDa and is expressed ubiquitously in human tissues with relatively higher levels observed in the brain. ZNF774 functions by binding to specific DNA sequences thereby regulating the transcription of target genes. As a member of the large family of zinc finger proteins it plays a significant role in modulating gene expression by interacting with DNA at the genetic promoter regions.

Biological function summary

Zinc Finger Protein 774 influences gene expression and transcriptional regulation. Researchers have shown that ZNF774 might interact with other proteins to form a transcriptional complex that modulates several important biological processes. This regulatory ability impacts cell cycle progression and differentiation processes that often require precise control of gene expression. By pairing with other DNA-binding proteins ZNF774 ensures proper genomic coordination and stability essential for cellular homeostasis.

Pathways

ZNF774 integrates into cellular and molecular pathways related to gene expression and regulation. An important pathway influenced by ZNF774 includes the p53 signaling pathway which involves cellular stress responses. ZNF774 interaction with proteins such as MDM2 highlights its role in this pathway. Additionally researchers have implicated ZNF774 in the mitogen-activated protein (MAP) kinase signaling pathway which is fundamental for various cellular activities like proliferation and differentiation. This pathway interaction suggests a wide-ranging impact of ZNF774 within cellular signaling networks.

Associated diseases and disorders

Researchers have linked Zinc Finger Protein 774 to certain neurological conditions and cancer. Its involvement in neurogenesis implicates ZNF774 in neurodevelopmental disorders potentially due to dysregulated gene expression affecting neural differentiation. In cancer the dysregulation of ZNF774 and its interaction with proteins such as p53 can contribute to disrupted cell cycle control leading to tumorigenesis. Further investigation into ZNF774's connection to these diseases can provide deeper insights into its role as a therapeutic target.