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AB223065

Anti-ZnT-7 antibody

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(1 Publication)

Rabbit Polyclonal ZnT-7 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC30A7 aa 150-250.

View Alternative Names

ZNT7, ZNTL2, SLC30A7, Zinc transporter 7, ZnT-7, Solute carrier family 30 member 7, Znt-like transporter 2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZnT-7 antibody (AB223065)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZnT-7 antibody (AB223065)

Paraffin-embedded human placental tissue stained for ZnT-7 using ab223065 at 1/100 in immunohistochemical analysis.

Western blot - Anti-ZnT-7 antibody (AB223065)
  • WB

Supplier Data

Western blot - Anti-ZnT-7 antibody (AB223065)

All lanes:

Western blot - Anti-ZnT-7 antibody (ab223065) at 1/1000 dilution

Lane 1:

Mouse heart tissue lysate

Lane 2:

Mouse skeletal muscle tissue lysate

Secondary

All lanes:

Goat Anti-Rabbit IgG at 1/50000 dilution

Predicted band size: 42 kDa

Observed band size: 42 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human SLC30A7 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.

Q8NEW0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZnT-7 also known as SLC30A7 is a zinc transporter protein responsible for decreasing cytosolic zinc levels by transporting zinc ions into the Golgi apparatus and trans-Golgi network. The molecular weight of ZnT-7 is approximately 45 kDa. It is expressed in many tissues with high levels found in the liver kidney and heart. The protein is localized mainly in the intracellular membranes playing a role in intracellular zinc homeostasis.
Biological function summary

ZnT-7 participates in the regulation of cellular zinc balance and is important for maintaining optimal enzyme activity and protein function. Although it does not form part of a larger complex itself it interacts with other zinc transporters to help coordinate zinc distribution within cells. This management of zinc levels is important for preventing zinc toxicity and supporting normal cellular activities which are dependent on zinc as a cofactor.

Pathways

ZnT-7 is involved in the zinc homeostasis pathway controlling the intracellular sequestration and distribution of zinc. It works alongside other zinc transporters such as ZnT-1 and ZIP family members to maintain appropriate intracellular zinc levels. ZnT-7 also affects the insulin signaling pathway as zinc ions are modulators of insulin storage and secretion in pancreatic beta cells.

Alterations in ZnT-7 function or expression have been linked to type 2 diabetes and prostate cancer. Disruption of zinc homeostasis due to ZnT-7 malfunction can contribute to metabolic dysfunctions and tumor development. The protein's interaction with other zinc transporters including ZnT-10 highlights its role in these conditions emphasizing the need for proper regulation of zinc levels in disease prevention and management.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway (PubMed : 15525635, PubMed : 15994300). By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases (PubMed : 15525635, PubMed : 15994300).
See full target information SLC30A7
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 13:7959 PubMed36575174

2022

PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression.

Applications

Unspecified application

Species

Unspecified reactive species

Lufei Sui,Suming Wang,Debolina Ganguly,Tyler P El Rayes,Cecilie Askeland,Astrid Børretzen,Danielle Sim,Ole Johan Halvorsen,Gøril Knutsvik,Jarle Arnes,Sura Aziz,Svein Haukaas,William D Foulkes,Diane R Bielenberg,Arturas Ziemys,Vivek Mittal,Rolf A Brekken,Lars A Akslen,Randolph S Watnick
View all publications
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Product promise

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