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AB237492

Anti-Znt6 antibody

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(1 Publication)

Rabbit Polyclonal ZNT6 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC30A6 aa 200 to C-terminus.

View Alternative Names

ZNT6, SLC30A6, Zinc transporter 6, ZnT-6, Solute carrier family 30 member 6

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Znt6 antibody (AB237492)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Znt6 antibody (AB237492)

Paraffin-embedded human colon cancer tissue stained for Znt6 using ab237492 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-Znt6 antibody (AB237492)
  • WB

Supplier Data

Western blot - Anti-Znt6 antibody (AB237492)

All lanes:

Western blot - Anti-Znt6 antibody (ab237492) at 1/500 dilution

Lane 1:

A549 (human lung carcinoma cell line) whole cell lysate

Lane 2:

U-251 MG (human brain glioma cell line) whole cell lysate

Secondary

All lanes:

Goat polyclonal to Rabbit IgG at 1/10000 dilution

Predicted band size: 51 kDa

false

Immunocytochemistry/ Immunofluorescence - Anti-Znt6 antibody (AB237492)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Znt6 antibody (AB237492)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for Znt6 (green) using ab237492 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488-congugated Goat Anti-Rabbit IgG (H+L) secondary antibody.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Znt6 antibody (AB237492)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Znt6 antibody (AB237492)

Paraffin-embedded human brain tissue stained for Znt6 using ab237492 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human SLC30A6 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6NXT4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity greater than 95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Znt6 also known as SLC30A6 is a zinc transporter protein involved in the homeostatic regulation of zinc ions. The protein has a molecular weight of approximately 45 kDa. Znt6 facilitates the transport of zinc ions across cellular membranes particularly into the Golgi apparatus and vesicles. This transporter is widely expressed in many tissues but its expression is notably high in the pancreas liver and brain.
Biological function summary

Znt6 plays a role in maintaining cellular zinc homeostasis. It is part of the cation diffusion facilitator (CDF) family involved in transporting metal ions within cells. Znt6 contributes to the sequestration of zinc into intracellular compartments which is important for zinc-dependent processes and enzyme functions. This protein is not known to be part of any larger complexes but works in coordination with other zinc transporters to balance intracellular zinc levels efficiently.

Pathways

Znt6 participates in cellular processes such as zinc ion transmembrane transport and metal ion homeostasis. It is linked to the regulation of pathways such as the MAPK signaling pathway which is influenced by zinc levels and the cellular response to oxidative stress. Proteins such as Znt7 another zinc transporter also interacts with related pathways ensuring the proper function of metalloenzymes and zinc-dependent cellular activities.

Znt6 has been associated with neurodegenerative diseases like Alzheimer's disease and metabolic disorders like diabetes. Dysregulation of zinc homeostasis in which Znt6 plays an important part can disrupt neuronal signaling and metal ion regulation. In Alzheimer's disease altered zinc transport involving Znt6 can affect amyloid-beta metabolism. In diabetes improper zinc regulation is linked to insulin granule formation and secretion. Proteins linked to zinc transporters like zinc transporter 8 (Znt8) also exhibit related dysfunctions in diabetes highlighting the interconnected role of Znt6 in disease states.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion : proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed : 15994300, PubMed : 19366695, PubMed : 19759014). As part of that zinc ion : proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed : 15994300, PubMed : 19759014, PubMed : 35525268).
See full target information SLC30A6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:10111 PubMed39578459

2024

Histone lactylation mediated by Fam172a in POMC neurons regulates energy balance.

Applications

Unspecified application

Species

Unspecified reactive species

Zhuo Chen,Baocheng Wan,Hong Zhang,Lina Zhang,Rong Zhang,Lianxi Li,Yi Zhang,Cheng Hu
View all publications
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