Anti-ZP2 antibody [EPR15467]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ZP2 also known as zona pellucida glycoprotein 2 is a structural protein critical to the protective coat surrounding oocytes called the zona pellucida. The protein is approximately 68 kDa in mass. ZP2 is highly expressed in the ovary. This glycoprotein specifically contributes to the matrix of the zona pellucida with other related proteins forming a structure that enables various reproductive events like sperm binding and prevention of polyspermy.

Biological function summary

ZP2 interacts with other zona pellucida proteins particularly ZP1 and ZP3 to form the zona pellucida matrix. This matrix allows the binding of sperm to the oocyte facilitating fertilization. The stability and integrity of this structure determine reproductive success and embryo development. ZP2 undergoes proteolytic cleavage during the fertilization process which is an important event for proper egg-sperm interaction.

Pathways

ZP2 forms an integral part of the fertilization pathway where it directly interacts with proteins ZP1 and ZP3. These proteins create a framework critical for sperm recognition and binding. Once ZP2 undergoes cleavage it assists in the progression of the acrosome reaction an important biological pathway for sperm penetration of the zona pellucida. The interactions and modifications of ZP2 within these pathways highlight the importance of precise regulation in reproduction.

Associated diseases and disorders

Mutations or abnormalities in ZP2 are linked to reproductive conditions such as infertility. These changes can lead to disrupted zona pellucida integrity which affects sperm binding and fertilization ability. Additionally abnormalities in ZP2 relate to oocyte maturation defects impacting reproductive health. The protein also shows interplay with ZP3 in these conditions underlining its collaborative role in maintaining fertility.