Anti-ZPR9 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ZPR9 also known as Zinc Finger Protein of Unknown Function 9 is a nuclear protein with a molecular mass of approximately 60 kDa. It contains zinc finger domains which serve as key structural motifs for binding to DNA. ZPR9 is expressed in various tissues including liver and brain but shows a higher expression in immune cells. It functions through specific DNA interactions regulating the transcriptional activity of several genes involved in cell growth and immune response.

Biological function summary

ZPR9 plays a role in managing cellular processes that include transcriptional regulation and cellular signaling. It often associates with other proteins to form complexes that modulate gene expression in response to external stimuli. Research has shown that ZPR9 interacts with components of the transcription machinery influencing numerous biological functions that encompass immune system modulation and cell cycle progression.

Pathways

ZPR9 contributes significantly to the MAPK signaling pathway and NF-kB pathway. In the MAPK pathway it connects with proteins such as ERK1/2 impacting cellular responses like proliferation and differentiation. In the NF-kB pathway ZPR9 has links with protein p65 contributing to the regulation of immune responses and inflammation. These connections indicate its integration in key signaling networks vital for cellular homeostasis and immune regulation.

Associated diseases and disorders

ZPR9 correlates with autoimmune diseases and cancer. Its abnormally high expression in conditions like rheumatoid arthritis suggests roles in inflammatory processes. Moreover alterations in ZPR9 expression have association with cancer development where it may impact tumor growth and metastasis. In autoimmune conditions it interacts with other proteins including NF-kB showing its influence on inflammatory pathways and potential as a therapeutic target.