Anti-ZRANB1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ZRANB1 also known as TRABID is a zinc finger RANBP2-type containing 1 protein with a mass of approximately 89 kDa. This protein functions majorly as a deubiquitinating enzyme specializing in cleaving Lys29- and Lys33-linked polyubiquitin chains. It is expressed across various tissues with notable expression in the human brain indicating its importance in neural functions. Mechanically ZRANB1 contains several zinc finger motifs which facilitate its interaction with ubiquitin substrates playing a critical role in protein ubiquitination homeostasis.

Biological function summary

ZRANB1 acts in the regulation of protein degradation and turnover impacting various cellular processes like signal transduction and cell cycle control. It functions as part of the ubiquitin-proteasome system which is a large multi-protein complex responsible for maintaining cellular protein homeostasis. Through its activity ZRANB1 influences not only regular cellular operations but also responds to stress signals by adjusting the degradation of proteins therefore impacting numerous physiological processes.

Pathways

ZRANB1 participates in the Wnt signaling pathway and the NF-kB pathway both of which are important for cell proliferation and immune response regulation. In the Wnt pathway it regulates the stability and signaling activity of key proteins like beta-catenin. Meanwhile ZRANB1's action in the NF-kB pathway involves modulating the degradation of ubiquitinated proteins with relations to proteins like NEMO. These pathways highlight the specific regulatory roles played by ZRANB1 within signaling networks.

Associated diseases and disorders

ZRANB1 has been implicated in cancer and neurological disorders. In cancer aberrant regulation or mutations in ZRANB1 can lead to uncontrolled cell growth due to misregulation of the Wnt signaling pathway. In neurological disorders potential links to proteins involved in neural development highlight its role in maintaining neural homeostasis. By influencing pathways connected to these diseases ZRANB1 interacts with other proteins such as APC in cancer and possibly tau proteins in neurodegenerative disorders.