Anti-ZSCAN4 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZSCAN4 also known as Zinc finger and SCAN domain-containing protein 4 plays a mechanical role in telomere maintenance and genomic stability. It has a molecular mass of approximately 55 kDa. Scientists observe ZSCAN4 expression mainly in embryonic stem cells and germ cells. The protein contains a SCAN domain and several zinc finger motifs that facilitate its binding to specific DNA sequences playing an important role in telomere elongation and genomic stability.

Biological function summary

ZSCAN4 connects to mechanisms vital for proper chromosome segregation and DNA repair. It also participates in the amplification of telomere repeats a process key for maintaining telomere length. ZSCAN4 can associate with complexes involved in chromatin remodeling and genomic reprogramming. Its function proves essential for the self-renewal and differentiation of pluripotent stem cells aiding the long-term maintenance of telomere integrity.

Pathways

ZSCAN4 integrates into the telomere extension and genomic stabilization pathways. Telomerase-related protein complexes interact with ZSCAN4 promoting telomere lengthening which slows down aging processes in cells. Additionally ZSCAN4 connects with the DNA repair machinery pathways that function to fix DNA damage and maintain genome integrity. Collaboration with proteins like TERT (Telomerase Reverse Transcriptase) and those in the SIRT (Sirtuin) family emphasize its cooperation in telomere biology and genomic stability.

ZSCAN4 has implications in cancer and age-related pathologies. Abnormal activation or suppression of ZSCAN4 leads to chromosomal instability a factor linked to cancer progression. In specific cancer types ZSCAN4 helps in bypassing senescence promoting indefinite cell proliferation. Furthermore researchers link ZSCAN4 activity to age-related disorders due to its role in telomere dynamics. In these contexts abnormalities in ZSCAN4 function often involve partnerships with proteins such as TERT and p53 which are key to telomere biology and tumor suppression.